Mixed connective tissue disease

In medicine, mixed connective tissue disease, commonly abbreviated as MCTD, is a serious autoimmune disease, in which the body's defense system attacks itself. It is also known as Sharp syndrome.

Additional recommended knowledge

Daily Visual Balance Check

How to ensure accurate weighing results every day?

Correct Test Weight Handling Guide: 12 Practical Tips

Clinical features

MCTD combines features of polymyositis, systemic lupus erythematosus, and systemic scleroderma and is thus considered an overlap syndrome.

MCTD commonly causes:

• joint pain/swelling,
• malaise,
• Raynaud phenomenon,
• muscle inflammation, and
• scarring of the skin of the hand.

It does not typically cause kidney disease or seizures.

Distinguishing laboratory characteristics are a positive, speckled anti-nuclear antibody and an anti-U1-RNP antibody.^[1]

References

1. ^ Venables PJ (2006). "Mixed connective tissue disease". Lupus 15 (3): 132–7. PMID 16634365.