MAPEG family

MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family of transmembrane proteins with highly divergent functions ^[1]. Included are the 5-lipoxygenase activating protein (gene FLAP), leukotriene C4 synthase (EC 2.5.1.37) that catalyzes the production of leukotriene C4 (LTC4) from leukotriene A4 (LTA4) and microsomal glutathione S-transferase II (EC 2.5.1.18) (GST-II) that also produces LTC4 from LTA4.

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Another example is prostaglandin E synthase. This enzyme catalyses the synthesis of PGE2 from PGH2 (produced by cyclooxygenase from arachidonic acid). Because of structural similarities in the active sites of FLAP, LTC4 synthase and PGE synthase, substrates for each enzyme can compete with one another and modulate synthetic activity.

Subfamilies

• 5-lipoxygenase-activating protein IPR001446

Human proteins containing this domain

ALOX5AP; LTC4S; MGST1; MGST2; MGST3; PTGES;

References

This article includes text from the public domain Pfam and InterPro IPR001129