Moritz Kaposi

Moritz Kaposi (Hungarian: Kaposi Mór) (b. 23 October 1837 in Kaposvár, Hungary; d. 6 March 1902 in Vienna, Austria) was an important Hungarian physician and dermatologist, discoverer of the skin tumor that received his name.

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Born to a Jewish family, originally his surname was Kohn, but with his conversion to the Catholic faith he changed it to Kaposi in 1871, in reference to his town of birth. One purported reason behind this is that he wanted to marry a daughter of current dermatology chairman, Ferdinand Ritter von Hebra, and advance in the society, which he could not have done being of Jewish faith. This seems unlikely in as much as he married Martha Hebra and converted to Catholicism several years prior to changing his name, by which time he was already well-established in the Vienna University faculty and a close associate of von Hebra. A more plausible explanation is based on his own comments to colleagues that he changed his name to avoid confusion with five other similarly named physicians on the Vienna faculty. Rumors about the sincerity of both his marriage and his concerns about his Jewish ancestry may have arisen through professional jealousy (William Dubreuilh (1857-1935), first professor and chairman of dermatology in Bordeaux: "On disait de Kaposi qu´il avait pris la fille de Hebra, sa maison, sa chaire et sa clientèle, laissant le reste à son beau-frère Hans Hebra.")

In 1855 Kaposi began to study medicine at the University of Vienna and attained a doctorate in 1859. In his dissertation, titled Dermatologie und Syphilis (1866) he made an important contribution to the field. Kaposi was appointed as professor at the University of Vienna in 1875, and in 1881 he became member of the board of the Vienna General Hospital and director of its clinic of skin diseases.

Together with his mentor, Ferdinand Ritter von Hebra, he authored the book Lehrbuch der Hautkrankheiten (Textbook of Skin Diseases) in 1878. Kaposi’s main work, however, was Pathologie und Therapie der Hautkrankheiten in Vorlesungen für praktische Ärzte und Studierende (Pathology and Therapy of the Skin Diseases in Lectures for Practical Physicians and Students), published in 1880, which became one of the most significant books in the history of dermatology, being translated to several languages. He is credited with the description of xeroderma pigmentosum, a rare genetic disorder now known to be caused by defects in nucleotide excision repair ("Ueber Xeroderma pigmentosum. Medizinische Jahrbücher, Wien, 1882: 619-633"). Among other diseases, Kaposi was the first to study Lichen scrofolosorum and Lupus erythematosus. In all, he published over 150 books and papers. He is widely credited with advancing the use of pathologic examination in the diagnosis of dermatologic diseases.

His name entered into the history of medicine in 1872, when he described for the first time Kaposi's sarcoma, a cancer of the skin, which he had discovered in five elderly male patients and which he initially named "idiopathic multiple pigmented sarcoma". More than a century later, the appearance of this disease in young gay men in New York, San Francisco and other coastal cities in the United States was one of the first indications that a new disease, now called AIDS, had appeared. Kaposi's sarcoma is tumor is caused by a virus, Kaposi's sarcoma-associated herpesvirus or KSHV discovered in 1993. Kaposi's sarcoma is now the most commonly reported cancer in parts of sub-Saharan Africa.

According to his biographer, Dr. J.D. Oriel, "in his lifetime, Moritz Kaposi was acknowledged as one of the great masters of the Vienna School of Dermatology, a superb clinician and renowned teacher". While his mentor Ferdinand von Hebra is considered the "father of dermatology", Kaposi was one of the first to establish dermatology on its anatomical pathology scientific basis. He became the chairman after Hebra's death in 1880.

Works

• Lehrbuch der Hautkrankheiten (1878 with Ferdinand von Hebra)
• Pathologie und Therapie der Hautkrankheiten in Vorlesungen für praktische Ärzte und Studierende (1880)
• Pathologie und Therapie der Syphilis (1881)
• Handatlas der Hautkrankenheiten (1879)
• Idiopathisches multiples Pigmentsarkom der Haut (1872) Arch Dermatol Syph 4:265-73 (original article describing Kaposi's sarcoma)
• English translation of article describing Kaposi's sarcoma: Kaposi M. Idiopathic multiple pigmented sarcoma of the skin. CA Cancer J Clin 1982;1982(32):342-7.

Bibliography

• Oriel JD. Moritz Kaposi (1837-1902). Int J STD AIDS. 1997 Nov;8(11):715-7. Medline abstract
• Holubar K and Fatovic-Ferencic S. Moriz Kaposi 1837-1902: a historical reappraisal [ http://www.oegdv.at/dl/history/histkaposi.doc]