List of EC numbers (EC 6)

This list contains a list of EC numbers for the sixth group, EC 6, ligases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.

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EC 6.1: Forming Carbon-Oxygen Bonds

EC 6.1.1: Ligases Forming Aminoacyl-tRNA and Related Compounds (Aminoacyl tRNA synthetase)

• EC 6.1.1.1: tyrosine-tRNA ligase
• EC 6.1.1.2: tryptophan-tRNA ligase
• EC 6.1.1.3: threonine-tRNA ligase
• EC 6.1.1.4: leucine-tRNA ligase
• EC 6.1.1.5: isoleucine-tRNA ligase
• EC 6.1.1.6: lysine-tRNA ligase
• EC 6.1.1.7: alanine-tRNA ligase
• EC 6.1.1.8: Deleted
• EC 6.1.1.9: valine-tRNA ligase
• EC 6.1.1.10: methionine-tRNA ligase
• EC 6.1.1.11: serine-tRNA ligase
• EC 6.1.1.12: aspartate-tRNA ligase
• EC 6.1.1.13: D-alanine-poly(phosphoribitol) ligase
• EC 6.1.1.14: glycine-tRNA ligase
• EC 6.1.1.15: proline-tRNA ligase
• EC 6.1.1.16: cysteine-tRNA ligase
• EC 6.1.1.17: glutamate-tRNA ligase
• EC 6.1.1.18: glutamine-tRNA ligase
• EC 6.1.1.19: arginine-tRNA ligase
• EC 6.1.1.20: phenylalanine-tRNA ligase
• EC 6.1.1.21: histidine-tRNA ligase
• EC 6.1.1.22: asparagine-tRNA ligase
• EC 6.1.1.23: aspartate-tRNAAsn ligase
• EC 6.1.1.24: glutamate-tRNAGln ligase
• EC 6.1.1.25: lysine-tRNAPyl ligase

EC 6.2: Forming Carbon-Sulfur Bonds

EC 6.2.1: Acid-Thiol Ligases

• EC 6.2.1.1: acetate-CoA ligase
• EC 6.2.1.2: butyrate-CoA ligase
• EC 6.2.1.3: long-chain-fatty-acid-CoA ligase
• EC 6.2.1.4: succinate-CoA ligase (GDP-forming)
• EC 6.2.1.5: succinate-CoA ligase (ADP-forming)
• EC 6.2.1.6: glutarate-CoA ligase
• EC 6.2.1.7: cholate-CoA ligase
• EC 6.2.1.8: oxalate-CoA ligase
• EC 6.2.1.9: malate-CoA ligase
• EC 6.2.1.10: acid-CoA ligase (GDP-forming)
• EC 6.2.1.11: biotin-CoA ligase
• EC 6.2.1.12: 4-coumarate-CoA ligase
• EC 6.2.1.13: acetate-CoA ligase (ADP-forming)
• EC 6.2.1.14: 6-carboxyhexanoate-CoA ligase
• EC 6.2.1.15: arachidonate-CoA ligase
• EC 6.2.1.16: acetoacetate-CoA ligase
• EC 6.2.1.17: propionate-CoA ligase
• EC 6.2.1.18: citrate-CoA ligase
• EC 6.2.1.19: long-chain-fatty-acid-luciferin-component ligase
• EC 6.2.1.20: long-chain-fatty-acid-(acyl-carrier-protein) ligase
• EC 6.2.1.21: Covered by EC 6.2.1.30
• EC 6.2.1.22: (citrate (pro-3S)-lyase) ligase
• EC 6.2.1.23: dicarboxylate-CoA ligase
• EC 6.2.1.24: phytanate-CoA ligase
• EC 6.2.1.25: benzoate-CoA ligase
• EC 6.2.1.26: o-succinylbenzoate-CoA ligase
• EC 6.2.1.27: 4-hydroxybenzoate-CoA ligase
• EC 6.2.1.28: 3a,7a-dihydroxy-5b-cholestanate-CoA ligase
• EC 6.2.1.29: Deleted, now EC 6.2.1.7
• EC 6.2.1.30: phenylacetate-CoA ligase
• EC 6.2.1.31: 2-furoate-CoA ligase
• EC 6.2.1.32: anthranilate-CoA ligase
• EC 6.2.1.33: 4-chlorobenzoate-CoA ligase
• EC 6.2.1.34: trans-feruloyl-CoA synthase

EC 6.3: Forming Carbon-Nitrogen Bonds

EC 6.3.1: Acid-Ammonia (or Amine) Ligases (Amide Synthases)

• EC 6.3.1.1: aspartate-ammonia ligase
• EC 6.3.1.2: glutamate-ammonia ligase
• EC 6.3.1.3: Now EC 6.3.4.13
• EC 6.3.1.4: aspartate-ammonia ligase (ADP-forming)
• EC 6.3.1.5: NAD+ synthase
• EC 6.3.1.6: glutamate-ethylamine ligase
• EC 6.3.1.7: 4-methyleneglutamate-ammonia ligase
• EC 6.3.1.8: glutathionylspermidine synthase
• EC 6.3.1.9: trypanothione synthase
• EC 6.3.1.10: adenosylcobinamide-phosphate synthase
• EC 6.3.1.11: glutamate-putrescine ligase

EC 6.3.2: Acid-Amino-Acid Ligases (Peptide Synthases)

• EC 6.3.2.1: pantoate-b-alanine ligase
• EC 6.3.2.2: glutamate-cysteine ligase
• EC 6.3.2.3: glutathione synthase
• EC 6.3.2.4: D-alanine-D-alanine ligase
• EC 6.3.2.5: phosphopantothenate-cysteine ligase
• EC 6.3.2.6: phosphoribosylaminoimidazolesuccinocarboxamide synthase
• EC 6.3.2.7: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase
• EC 6.3.2.8: UDP-N-acetylmuramate-L-alanine ligase
• EC 6.3.2.9: UDP-N-acetylmuramoylalanine-D-glutamate ligase
• EC 6.3.2.10: UDP-N-acetylmuramoylalanyl-tripeptide-D-alanyl-D-alanine ligase
• EC 6.3.2.11: carnosine synthase
• EC 6.3.2.12: dihydrofolate synthase
• EC 6.3.2.13: UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diamino-pimelate ligase
• EC 6.3.2.14: 2,3-dihydroxybenzoate-serine ligase
• EC 6.3.2.15: Deleted, due to EC 6.3.2.10
• EC 6.3.2.16: D-alanine-alanyl-poly(glycerolphosphate) ligase
• EC 6.3.2.17: tetrahydrofolate synthase
• EC 6.3.2.18: g-glutamylhistamine synthase
• EC 6.3.2.19: ubiquitin-protein ligase
• EC 6.3.2.20: indoleacetate-lysine synthetase
• EC 6.3.2.21: ubiquitin-calmodulin ligase
• EC 6.3.2.22: diphthine-ammonia ligase
• EC 6.3.2.23: homoglutathione synthase
• EC 6.3.2.24: tyrosine-arginine ligase
• EC 6.3.2.25: tubulin-tyrosine ligase
• EC 6.3.2.26: N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase
• EC 6.3.2.27: aerobactin synthase

EC 6.3.3: Cyclo-Ligases

• EC 6.3.3.1: phosphoribosylformylglycinamidine cyclo-ligase
• EC 6.3.3.2: 5-formyltetrahydrofolate cyclo-ligase
• EC 6.3.3.3: dethiobiotin synthase
• EC 6.3.3.4: (carboxyethyl)arginine b-lactam-synthase

EC 6.3.4: Other Carbon-Nitrogen Ligases

• EC 6.3.4.1: GMP synthase
• EC 6.3.4.2: CTP synthase
• EC 6.3.4.3: formate-tetrahydrofolate ligase
• EC 6.3.4.4: adenylosuccinate synthase
• EC 6.3.4.5: argininosuccinate synthase
• EC 6.3.4.6: urea carboxylase
• EC 6.3.4.7: ribose-5-phosphate-ammonia ligase
• EC 6.3.4.8: imidazoleacetate-phosphoribosyldiphosphate ligase
• EC 6.3.4.9: biotin-(methylmalonyl-CoA-carboxytransferase) ligase
• EC 6.3.4.10: biotin-(propionyl-CoA-carboxylase (ATP-hydrolysing)) ligase
• EC 6.3.4.11: biotin-(methylcrotonoyl-CoA-carboxylase) ligase
• EC 6.3.4.12: glutamate-methylamine ligase
• EC 6.3.4.13: phosphoribosylamine-glycine ligase
• EC 6.3.4.14: biotin carboxylase
• EC 6.3.4.15: biotin-(acetyl-CoA-carboxylase) ligase
• EC 6.3.4.16: carbamoyl-phosphate synthase (ammonia)
• EC 6.3.4.17: formate-dihydrofolate ligase

EC 6.3.5: Carbon-Nitrogen Ligases with Glutamine as Amido-N-Donor

• EC 6.3.5.1: NAD+ synthase (glutamine-hydrolysing)
• EC 6.3.5.2: GMP synthase (glutamine-hydrolysing)
• EC 6.3.5.3: phosphoribosylformylglycinamidine synthase
• EC 6.3.5.4: asparagine synthase (glutamine-hydrolysing)
• EC 6.3.5.5: carbamoyl-phosphate synthase (glutamine-hydrolysing)
• EC 6.3.5.6: asparaginyl-tRNA synthase (glutamine-hydrolysing)
• EC 6.3.5.7: glutaminyl-tRNA synthase (glutamine-hydrolysing)
• EC 6.3.5.8: aminodeoxychorismate synthase
• EC 6.3.5.9: hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing)
• EC 6.3.5.10: adenosylcobyric acid synthase (glutamine-hydrolysing)

EC 6.4: Forming Carbon-Carbon Bonds

• EC 6.4.1.1: pyruvate carboxylase
• EC 6.4.1.2: acetyl-CoA carboxylase
• EC 6.4.1.3: propionyl-CoA carboxylase
• EC 6.4.1.4: methylcrotonoyl-CoA carboxylase
• EC 6.4.1.5: geranoyl-CoA carboxylase
• EC 6.4.1.6: acetone carboxylase

EC 6.5: Forming Phosphoric Ester Bonds

• EC 6.5.1.1: DNA ligase (ATP)
• EC 6.5.1.2: DNA ligase (NAD+)
• EC 6.5.1.3: RNA ligase (ATP)
• EC 6.5.1.4: RNA-3'-phosphate cyclase

EC 6.6: Forming Nitrogen-Metal Bonds

EC 6.6.1: Forming Coordination Complexes

• EC 6.6.1.1: magnesium chelatase
• EC 6.6.1.2: cobaltochelatase