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LFA-1

LFA-1 stands for Lymphocyte function-associated antigen-1.

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LFA-1 is found on all T-cells and also on B-cells, macrophages and neutrophils and is involved in recruitment to the site of infection. It binds to ICAM-1 on antigen-presenting cells and functions as an adhesion molecule, it is the first to bind T-cells to antigen-presenting cells and initially binds weakly. A signal from the T-cell receptor changes the conformation and prolongs the cell contact, allowing the T-cell to proliferate.

LFA-1 is part of the family of leukocyte integrins which are recognised by their common β-chains (CD18). LFA-1 also has a distinct α-chain (CD11a).

External links

MeSH LFA-1
Davignon D, Martz E, Reynolds T, Kürzinger K, Springer TA (1981). "Lymphocyte function-associated antigen 1 (LFA-1): a surface antigen distinct from Lyt-2,3 that participates in T lymphocyte-mediated killing". Proc. Natl. Acad. Sci. U.S.A. 78 (7): 4535–9. PMID 7027264.

v • d • e Transmembrane receptors: immune receptors
Cytokine receptor	Type I: interleukin (IL-2, IL-3) - CSF (Erythropoietin, GM-CSF, G-CSF) - Glycoprotein 130/Oncostatin M - Leukemia inhibitory factor - common subunits (Common gamma chain, CSF2RB) Type II: interleukin (IL22RA2) - interferon (IFNAR, IFNGR) Other: Chemokine - TGF-beta - Tumor necrosis factor
Pattern recognition/Toll-like	TLR 1 - TLR 2 - TLR 3 - TLR 4 - TLR 5 - TLR 6 - TLR 7 - TLR 8 - TLR 9 - TLR 10
Fc receptor	ε (FcεRI, FcεRII) - γ (FcγRI, FcγRII, FcγRIII) - α/μ (FcαRI, Fcα/μR) - Neonatal
Lymphocyte homing receptor	CD44 - L-selectin - VLA-4 - LFA-1
other	Antigen receptor (B-cell, T cell) - Complement - Formyl peptide - Immunophilins - Integrin - Killer-cell immunoglobulin-like - Scavenger

v • d • e Membrane proteins: cell adhesion molecules
IgSF	N-CAM (Myelin protein zero) - ICAM (1, 4) - VCAM-1 - PE-CAM - L1-CAM
Cadherins	Desmoglein - T-cadherin - protocadherin
Selectins	E-selectin - L-selectin - P-selectin
Integrins	LFA-1 - Integrin alphaXbeta2 - Macrophage-1 antigen - VLA-4 - Glycoprotein IIb/IIIa (Note: integrins not always classified as CAMs)
Other	Carcinoembryonic antigen - CD22 - CD24 - CD44 - CD146 - CD164

Categories: Cell signaling | Signal transduction | Immunology

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "LFA-1". A list of authors is available in Wikipedia.