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Keratin 8




Keratin 8
Identifiers
Symbol(s) KRT8; K8; CARD2; CK8; CYK8; K2C8; KO
External IDs OMIM: 148060 MGI: 96705 Homologene: 55643
Orthologs
Human Mouse
Entrez 3856 16691
Ensembl na ENSMUSG00000049382
Uniprot na P11679
Refseq NM_002273 (mRNA)
NP_002264 (protein) 		NM_031170 (mRNA)
NP_112447 (protein)
Location na Chr 15: 101.82 - 101.83 Mb
Pubmed search [1] [2]

Keratin 8 is a keratin protein often paired with keratin 18.



Further reading

  • Moll R, Franke WW, Schiller DL, et al. (1983). "The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells.". Cell 31 (1): 11-24. PMID 6186379.
  • Ljubimov AV, Bartek J, Couchman JR, et al. (1992). "Distribution of individual components of basement membrane in human colon polyps and adenocarcinomas as revealed by monoclonal antibodies.". Int. J. Cancer 50 (4): 562-6. PMID 1371500.
  • Smedts F, Ramaekers F, Robben H, et al. (1990). "Changing patterns of keratin expression during progression of cervical intraepithelial neoplasia.". Am. J. Pathol. 136 (3): 657-68. PMID 1690513.
  • Krauss S, Franke WW (1990). "Organization and sequence of the human gene encoding cytokeratin 8.". Gene 86 (2): 241-9. PMID 1691124.
  • Yamamoto R, Kao LC, McKnight CE, Strauss JF (1990). "Cloning and sequence of cDNA for human placental cytokeratin 8. Regulation of the mRNA in trophoblastic cells by cAMP.". Mol. Endocrinol. 4 (3): 370-4. PMID 1692965.
  • Waseem A, Alexander CM, Steel JB, Lane EB (1991). "Embryonic simple epithelial keratins 8 and 18: chromosomal location emphasizes difference from other keratin pairs.". New Biol. 2 (5): 464-78. PMID 1705144.
  • Tsubura A, Okada H, Sasaki M, et al. (1991). "Immunohistochemical demonstration of keratins 8 and 14 in benign tumours of the skin appendage.". Virchows Archiv. A, Pathological anatomy and histopathology 418 (6): 503-7. PMID 1711732.
  • Leube RE, Bosch FX, Romano V, et al. (1987). "Cytokeratin expression in simple epithelia. III. Detection of mRNAs encoding human cytokeratins nos. 8 and 18 in normal and tumor cells by hybridization with cDNA sequences in vitro and in situ.". Differentiation 33 (1): 69-85. PMID 2434381.
  • Guelstein VI, Tchypysheva TA, Ermilova VD, et al. (1988). "Monoclonal antibody mapping of keratins 8 and 17 and of vimentin in normal human mammary gland, benign tumors, dysplasias and breast cancer.". Int. J. Cancer 42 (2): 147-53. PMID 2456993.
  • Osborn M, Mazzoleni G, Santini D, et al. (1988). "Villin, intestinal brush border hydrolases and keratin polypeptides in intestinal metaplasia and gastric cancer; an immunohistologic study emphasizing the different degrees of intestinal and gastric differentiation in signet ring cell carcinomas.". Virchows Archiv. A, Pathological anatomy and histopathology 413 (4): 303-12. PMID 2459839.
  • Fisher HP, Doppl W, Osborn M, Altmannsberger M (1989). "Evidence for a hepatocellular lineage in a combined hepatocellular-cholangiocarcinoma of transitional type.". Virchows Arch., B, Cell Pathol. 56 (2): 71-6. PMID 2467436.
  • Kulesh DA, Ceceña G, Darmon YM, et al. (1989). "Posttranslational regulation of keratins: degradation of mouse and human keratins 18 and 8.". Mol. Cell. Biol. 9 (4): 1553-65. PMID 2471065.
  • Gel'shteĭn VI, Chipysheva TA, Ermilova VD, Bannikov GA (1990). "[The expression of keratins Nos. 8, 17 and vimentin in pleomorphic adenoma of the salivary glands]". Arkh. Patol. 51 (10): 28-35. PMID 2482017.
  • Eichbaum QG, Beatty DW, Parker MI (1994). "Identification of cardiac autoantigens in human heart cDNA libraries using acute rheumatic fever sera.". J. Autoimmun. 7 (2): 243-61. doi:10.1006/jaut.1994.1019. PMID 8037842.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
  • Ku NO, Omary MB (1997). "Phosphorylation of human keratin 8 in vivo at conserved head domain serine 23 and at epidermal growth factor-stimulated tail domain serine 431.". J. Biol. Chem. 272 (11): 7556-64. PMID 9054461.
  • Ji H, Reid GE, Moritz RL, et al. (1997). "A two-dimensional gel database of human colon carcinoma proteins.". Electrophoresis 18 (3-4): 605-13. doi:10.1002/elps.1150180344. PMID 9150948.
  • Liao J, Ku NO, Omary MB (1997). "Stress, apoptosis, and mitosis induce phosphorylation of human keratin 8 at Ser-73 in tissues and cultured cells.". J. Biol. Chem. 272 (28): 17565-73. PMID 9211903.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
v • d • e
Protein: fibrous proteins
CollagenType-I (COL1A1) - Type-II (COL2A1) - Type-III - Type-IV - Type-V - Type XI (COL11A2) - Type-XVII - Type-XVIII
Keratin/Cytokeratintype I (10, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21), type II (1, 2A, 3, 4, 5, 6A, 7, 8, 9), Hair (Type I, Type II), Beta
otherElastin - Cytoskeletal
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Keratin_8". A list of authors is available in Wikipedia.
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