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Intersalt study

The Intersalt study was a landmark observational study that showed a strong association between dietary salt and risk of cardiovascular disease.^[1] The results were disputed by the Salt Institute (the salt producers' trade organisation), who demanded that the results be handed over for re-analysis.^[2] A re-analysis was published in 1996 and the results were the same.^[3] The results have since been confirmed by the TOHP I and TOHP II studies.^[4]

References

^ Intersalt Cooperative Research Group (1988). "Intersalt: an international study of electrolyte excretion and blood pressure. Results for 24 hour urinary sodium and potassium excretion". Br Med J 297 (6644): 319–28. PMID 3416162.
^ Godlee F (2007). "Editor's choice: Time to talk salt". Br Med J 334 (7599). doi:10.1136/bmj.39196.679537.47.
^ Elliott P, Stamler J, Nichols R, et al. (1996). "Intersalt revisited: further analyses of 24 hour sodium excretion and blood pressure within and across populations. Intersalt Cooperative Research Group". Br Med J 312 (7041): 1249–53. PMID 8634612.
^ Cook NR, Cutler JA, Obarzanek E, et al. (2007). "Long term effects of dietary sodium reduction on cardiovascular disease outcomes: observational follow-up of the trials of hypertension prevention (TOHP)". Br Med J 334: 885–8. doi:10.1136/bmj.39147.604896.55.