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HypromelloseHypromellose, short for hydroxypropyl methylcellulose (HPMC), is a semisynthetic, inert, viscoelastic polymer used as an ophthalmic lubricant, as well as an excipient and controlled-delivery component in oral medicaments, found in a variety of commercial products.[1][2] Additional recommended knowledgeOphthalmic applicationsHypromellose solutions were patented as a semisynthetic substitute for tear-film.[3] Its molecular structure is predicated upon a base celluloid compound that is highly water soluble. Post-application, celluloid attributes of good water solubility reportedly aids in visual clarity. When applied, a hypromellose solution acts to swell and absorb water, thereby expanding the thickness of the tear-film. Hypromellose augmentation therefore results in extended lubricant time presence on the cornea, which theoretically results in decreased eye irritation, especially in dry climates, home, or work environments.[4] On a molecular level, this polymer contains beta-linked D-glucose units that remain metabolically intact for days to weeks. On a manufacturing note, since hypromellose is a vegetarian substitute for gelatin, it is slightly more expensive to produce due to semisynthetic manufacturing processes. Aside from its widespread commercial and retail availability over the counter in a variety of products, Hypromellose 2% solution has been documented to be used during surgery to aid in corneal protection and during orbital surgery. Excipient/Tableting ingredientIn addition to its use in ophthalmic liquids, hypromellose has been used as an ingredient in oral tablet and capsule formulations, where it functions to delay the release of a medicinal compound into the digestive tract. References
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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Hypromellose". A list of authors is available in Wikipedia. |