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Hitachimycin


Hitachimycin
Systematic (IUPAC) name
(2Z,4E,6E,12E)-16,20-dihydroxy-21-methoxy- 3-methyl-10-phenyl-9-azabicyclo[17.3.0] docosa-2,4,6,12,19-pentaene-8,18-dione
Identifiers
CAS number	77642-19-4
ATC code	?
PubChem	5384563
Chemical data
Formula	C₂₉H₃₅NO₅
Mol. mass	477.592 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Hitachimycin, also known as stubomycin, is a cyclic polypeptide produced by Streptomyces that acts as an antibiotic. It exhibits cytotoxic activity against mammalian cells, Gram-positive bacteria, yeast, and fungi, as well as hemolytic activity; this is mediated by changes at the cell membrane and subsequent lysis.^[1] Owing to its cytotoxic activity against mammalian cells and tumors, it was first proposed as a antitumor antibiotic.^[2]

As of 2007, it has not been used in a clinical setting.

References

^ Komiyama K, Edanami K, Tanoh A, Yamamoto H, Umezawa I (1983). "Studies on the biological activity of stubomycin". J. Antibiot. 36 (3): 301-11. PMID 6833150.
^ Umezawa I, Takeshima H, Komiyama K, Koh Y, Yamamoto H, Kawaguchi M (1981). "A new antitumor antibiotic, stubomycin". J. Antibiot. 34 (3): 259-65. PMID 7275806.

v • d • e Antibacterials for systemic use: others (J01X)
Glycopeptide	Vancomycin - Teicoplanin
Polymyxins	Colistin - Polymyxin B
Steroid antibacterials	Fusidic acid
Imidazole derivatives	Metronidazole - Tinidazole - Ornidazole
Nitrofuran derivatives	Nitrofurantoin - Nifurtoinol
Other	Fosfomycin - Xibornol - Clofoctol - Spectinomycin - Methenamine - Mandelic acid - Nitroxoline - Linezolid - Daptomycin - Hitachimycin - Dalbavancin - Telavancin