Hemorrhagic cystitis

Hemorrhagic cystitis or Haemorrhagic cystitis is diffuse inflammation of the bladder leading to hemorrhage. This is seen most often in cancer patients as a complication of therapy. It occurs in women. Pus is present in the urine but no organism can be cultured in the urine

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Causes of hemorrhagic cystitis include chemotherapy (e.g. cyclophosphamide), radiation, or viral infection (e.g. with the [[BK virus] or Adenovirus] in bone marrow transplant patients. In the case of hemorrhagic cystitis from cyclophosphamide, this can be prevented through aggressive hydration and the use of mesna, which neutralizes the toxicity of acrolein, a metabolite of cyclophosphamide.