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HLA-DR5



  HLA-DR5 (DR5) is a broad-antigen serotype that is further split into HLA-DR11 and HLA-DR12 antigen serotypes.

Contents

Serology

DR11, DR5 and DR12 recognition of the gene products of some DRB1*11 and DRB1*12 alleles[1]
DRB1* DR11 DR5 DR12 Sample
allele % % % size (N)
1101 92 5 3474
1102 89 3 430
1103 89 4 397
1104 87 4 2119
1105 75 4
1106 20 73 15
1107 >50 1
1108 >50 2
1109 80 20 5
.
DR12 DR5 DR11 Sample
1201 83 4 2 893 [2]
1202 89 162
1203 >50 3
1206 >50 2

With the exception of a few DRB1* alleles the reactivity of DR5 is relatively poor.

Disease associations

DR5 is associated with persistent generalized lymphadenopathy (PGL)[3] and Kaposi sarcoma in AIDS[4], juvenile rheumatoid arthritis[5][6], Hashimoto's thyroiditis[7][8], mycosis fungoides[9], polyglandular deficiency syndrome[10], systemic sclerosis[11][12], childhood epilepsy[13], early-onset alopecia areata[14], short-ragweed Ra6 allergy[15], primary antiphospholipid syndrome[16], and increased longevity in the Dutch[17]

Genetic linkage

HLA-DR5 reactive gene products are linked to serology of HLA-DRB3 (HLA-DR52).

References

  1. ^ derived from IMGT/HLA
  2. ^ DR8 - 2%
  3. ^ Raffoux C, David V, Couderc L, Rabian C, Clauvel J, Seligmann M, Colombani J (1987). "HLA-A, B and DR antigen frequencies in patients with AIDS-related persistent generalized lymphadenopathy (PGL) and thrombocytopenia.". Tissue Antigens 29 (1): 60-2. PMID 3495904.
  4. ^ Pollack M, Safai B, Myskowski P, Gold J, Pandey J, Dupont B (1983). "Frequencies of HLA and Gm immunogenetic markers in Kaposi's sarcoma.". Tissue Antigens 21 (1): 1-8. PMID 6601312.
  5. ^ Førre O, Dobloug J, Høyeraal H, Thorsby E (1983). "HLA antigens in juvenile arthritis. Genetic basis for the different subtypes.". Arthritis Rheum 26 (1): 35-8. PMID 6401993.
  6. ^ Suciu-Foca N, Jacobs J, Godfrey M, Woodward K, Khan R, Reed E, Rohowsky C (1980). "HLA-DR5 in juvenile rheumatoid arthritis confined to few joints.". Lancet 2 (8184): 40. PMID 6104257.
  7. ^ Farid N, Sampson L, Moens H, Barnard J (1981). "The association of goitrous autoimmune thyroiditis with HLA-DR5.". Tissue Antigens 17 (3): 265-8. PMID 6947505.
  8. ^ Schleusener H, Schernthaner G, Mayr W, Kotulla P, Bogner U, Finke R, Meinhold H, Koppenhagen K, Wenzel K (1983). "HLA-DR3 and HLA-DR5 associated thyrotoxicosis--two different types of toxic diffuse goiter.". J Clin Endocrinol Metab 56 (4): 781-5. PMID 6131902.
  9. ^ Safai B, Myskowski P, Dupont B, Pollack M (1983). "Association of HLA-DR5 with mycosis fungoides.". J Invest Dermatol 80 (5): 395-7. PMID 6601679.
  10. ^ Shapiro M, Zamir R, Weiss E, Radnay J, Shenkman L (1987). "The polyglandular deficiency syndrome: a new variant in Persian Jews.". J Endocrinol Invest 10 (1): 1-7. PMID 3496374.
  11. ^ Pereira S, Black C, Welsh K, Ansell B, Jayson M, Maddison P, Rowell N (1987). "Autoantibodies and immunogenetics in 30 patients with systemic sclerosis and their families.". J Rheumatol 14 (4): 760-5. PMID 3499513.
  12. ^ Luderschmidt C, Scholz S, Mehlhaff E, König G, Albert E (1987). "Association of progressive systemic scleroderma to several HLA-B and HLA-DR alleles.". Arch Dermatol 123 (9): 1188-91. PMID 3498440.
  13. ^ Minev M, Martinova F, Belopitova L. "On the association of the HLA system with epilepsy in children.". Epilepsia 28 (1): 74-6. PMID 3098558.
  14. ^ Orecchia G, Belvedere M, Martinetti M, Capelli E, Rabbiosi G (1987). "Human leukocyte antigen region involvement in the genetic predisposition to alopecia areata.". Dermatologica 175 (1): 10-4. PMID 3497062.
  15. ^ Marsh D, Freidhoff L, Ehrlich-Kautzky E, Bias W, Roebber M (1987). "Immune responsiveness to Ambrosia artemisiifolia (short ragweed) pollen allergen Amb a VI (Ra6) is associated with HLA-DR5 in allergic humans.". Immunogenetics 26 (4-5): 230-6. PMID 3498688.
  16. ^ Vargas-Alarcon G, Granados J, Bekker C, Alcocer-Varela J, Alarcón-Segovia D (1995). "Association of HLA-DR5 (possibly DRB1*1201) with the primary antiphospholipid syndrome in Mexican patients.". Arthritis Rheum 38 (9): 1340-1. PMID 7575732.
  17. ^ Lagaay A, D'Amaro J, Ligthart G, Schreuder G, van Rood J, Hijmans W. "Longevity and heredity in humans. Association with the human leucocyte antigen phenotype.". Ann N Y Acad Sci 621: 78-89. PMID 1859103.
v • d • e
HLA DR Serotypes
DR - DR1 - DR2 - DR3 - DR4 - DR5 - DR6 - DR7 - DR8 - DR9 - DR10 - DR11 - DR12 - DR13 - DR14 - DR15 - DR16 - DR17 - DR18 - DR51 - DR52 - DR53
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "HLA-DR5". A list of authors is available in Wikipedia.
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