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HLA-DR3
HLA-DR3 is composed to the HLA-DR17 and HLA-DR18 split 'antigens' serotypes.
Additional recommended knowledge
Serology
Some DR3 also react with HLA-DR17 and/or HLA-DR18. The DRB1*0304 primarily reacts with DR3. The serotypes of *0305, *0306, *0308 to *0331 are unknown. Disease associationsBy serotypeHLA-DR3 is associated with early-age onset myasthenia gravis, primary sclerosing cholangitis,[2] and opportunistic infections in AIDS[3], but lowered risk for cancers[4]. By alleleDRB1*0301 (see HLA-DR17) DRB1*0302 (See HLA-DR18) DRB1*0304 is associated it graves disease[5] By haplotypesDR3 and/or DQ2 is associated with Moreen's ulceration[6], "bout onset" multiple sclerosis[7], Grave's disease[8] and systemic lupus erythematosus[9] DR3-DQ2 linkage is associated with coeliac disease, dermatitis herpetiformis, juvenile diabetes. DR3-DR2 is the serological marker for HLA-DQ2.5cis isoform. Although it cannot identify the alpha ".5" chain of HLA DQ, DQA1*0501 gene is almost always found within the DR3-DQ2 haplotype Eurasia (however is older studies DQA1*0505 is commonly confused with DQA1*0501) Genetic linkageDR3 is genetically linked to HLA-DR52, DRB3*0202 allele, and HLA-DQ2 (DQ2.5). References
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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "HLA-DR3". A list of authors is available in Wikipedia. |