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HLA-DR3



major histocompatibility complex, class II, DR3
Haplotypes groups	DRA01:DRB10301 DRA01:DRB10302 DRA01:DRB10303 DRA01:DRB10304
Structure (See HLA-DR)
Identifiers	alpha *0101
Symbol(s)	HLA-DRA
EBI-HLA	DRA*0101
Identifiers	beta 1 0301 0301 0302 0303 *0304
Symbol(s)	HLA-DRB1
EBI-HLA	DRB1*0301
EBI-HLA	DRB1*0302
EBI-HLA	DRB1*0303
EBI-HLA	DRB1*0304
EBI-HLA	DRB1*0305
Shared data
Locus	chr.6 6p21.31

HLA-DR3 is composed to the HLA-DR17 and HLA-DR18 split 'antigens' serotypes.

Additional recommended knowledge

Essential Laboratory Skills Guide

What is the Correct Way to Check Repeatability in Balances?

Serology

DR17 and DR3 recognition of some DRB1*03 alleles^[1]
DRB1*	DR3	DR17	DR18	Sample
allele	%	%	%	size (N)
0301	33	64	0	9698
0302	24	3	66	317
0303	40		60	5
0304	60	20		5
0307	>50			1

Some DR3 also react with HLA-DR17 and/or HLA-DR18. The DRB1*0304 primarily reacts with DR3. The serotypes of *0305, *0306, *0308 to *0331 are unknown.

Disease associations

By serotype

HLA-DR3 is associated with early-age onset myasthenia gravis, primary sclerosing cholangitis,^[2] and opportunistic infections in AIDS^[3], but lowered risk for cancers^[4].

By allele

DRB1*0301 (see HLA-DR17)

DRB1*0302 (See HLA-DR18)

DRB1*0304 is associated it graves disease^[5]

By haplotypes

DR3 and/or DQ2 is associated with Moreen's ulceration^[6], "bout onset" multiple sclerosis^[7], Grave's disease^[8] and systemic lupus erythematosus^[9]

DR3-DQ2 linkage is associated with coeliac disease, dermatitis herpetiformis, juvenile diabetes. DR3-DR2 is the serological marker for HLA-DQ2.5cis isoform. Although it cannot identify the alpha ".5" chain of HLA DQ, DQA1*0501 gene is almost always found within the DR3-DQ2 haplotype Eurasia (however is older studies DQA1*0505 is commonly confused with DQA1*0501)
PubMed

Genetic linkage

DR3 is genetically linked to HLA-DR52, DRB3*0202 allele, and HLA-DQ2 (DQ2.5).

References

^ derived from IMGT/HLA
^ Wiencke K, Karlsen TH, Boberg KM, et al (2007). "Primary sclerosing cholangitis is associated with extended HLA-DR3 and HLA-DR6 haplotypes". Tissue Antigens 69 (2): 161-9. doi:10.1111/j.1399-0039.2006.00738.x. PMID 17257319.
^ Pollack MS, Gold J, Metroka CE, Safai B, Dupont B (1984). "HLA-A,B,C and DR antigen frequencies in acquired immunodeficiency syndrome (AIDS) patients with opportunistic infections". Hum. Immunol. 11 (2): 99-103. PMID 6333416.
^ Mann DL, Murray C, O'Donnell M, Blattner WA, Goedert JJ (1990). "HLA antigen frequencies in HIV-1-related Kaposi's sarcoma". J. Acquir. Immune Defic. Syndr. 3 Suppl 1: S51-5. PMID 2395088.
^ "{{{title}}}". PMID 10468973.
^ Taylor C, Smith S, Morgan C, Stephenson S, Key T, Srinivasan M, Cunningham E, Watson P (2000). "HLA and Mooren's ulceration.". Br J Ophthalmol 84 (1): 72-5. PMID 10611103.
^ Weinshenker B, Santrach P, Bissonet A, McDonnell S, Schaid D, Moore S, Rodriguez M (1998). "Major histocompatibility complex class II alleles and the course and outcome of MS: a population-based study.". Neurology 51 (3): 742-7. PMID 9748020.
^ Ratanachaiyavong S, Lloyd L, Darke C, McGregor A (1993). "MHC-extended haplotypes in families of patients with Graves' disease.". Hum Immunol 36 (2): 99-111. PMID 8096501.
^ Tjernström F, Hellmer G, Nived O, Truedsson L, Sturfelt G (1999). "Synergetic effect between interleukin-1 receptor antagonist allele (IL1RN*2) and MHC class II (DR17,DQ2) in determining susceptibility to systemic lupus erythematosus.". Lupus 8 (2): 103-8. PMID 10192503.

v • d • e HLA DR Serotypes
DR - DR1 - DR2 - DR3 - DR4 - DR5 - DR6 - DR7 - DR8 - DR9 - DR10 - DR11 - DR12 - DR13 - DR14 - DR15 - DR16 - DR17 - DR18 - DR51 - DR52 - DR53

Category: HLA-DR haplotypes

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "HLA-DR3". A list of authors is available in Wikipedia.