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HLA-DR12


major histocompatibility complex, class II, DR12
Haplotypes groups	DQA01:DRB11201 to DQA01:DRB11203 DQA01:DRB11206
Structure (See HLA-DR)
Identifiers	alpha *0101
Symbol(s)	HLA-DRA
EBI-HLA	DRA*0101
Identifiers	beta 1 1201 to 1203 *1206
Symbol(s)	HLA-DRB1
EBI-HLA	DRB1*1201
EBI-HLA	DRB1*1202
EBI-HLA	DRB1*1203
EBI-HLA	DRB1*1306
Shared data
Locus	chr.6 6p21.31

HLA-DR12(DR12) is a HLA-DR serotype that recognizes the DRB1*1201 to *1203, *1206. DR12 serotype is a split antigen of the older HLA-DR5 serotype group which also contains the similar HLA-DR11 antigens.

Additional recommended knowledge

Daily Sensitivity Test

What is the Correct Way to Check Repeatability in Balances?

Serology

DR12, DR5 and DR11 serotype recognition of the gene products of some DRB1*12 alleles^[1]
DRB1*	DR12	DR5	DR11	Sample
allele	%	%	%	size (N)
1201	83	4	2	893 ^[2]
1202	89			162
1203	>50			3
1206	>50			2

The table above describes the efficiency of serological typing of DR12 and DR5. Serotypes are unknown the following alleles: DRB1*1204,*1205 to *1207 to *1215

Alleles

There are only 2 common allels for DRB1*12, *1201 and *1202. *1202 is more common on the West Pacific Rim and particularly Indochina and the South Pacific.

Disease associations

DR12 is associated with vulval lichen sclerosus, ^[3] and undifferentiated spondyloarthritis.^[4]

DRB1*1201 is associated with iritis in juvenile arthritis^[5],primary antiphospholipid syndrome^[6], tiopronin intolerance in rheumatoid arthritis,^[7] adult chronic articular Still's disease^[8]

DRB1*1202 is found to be increased in narcolepsy associated sudden death syndrome in the Thai population,^[9] and narcolepsy in the Japanese population.

Extended linkage

DRB1*12:DQA1*0505:DQBA1*0301 haplotype: DR12-DQ7.5/DR7-DQ2.2 is a transhaplotype risk for coeliac disease^[10]

DRB1*1201:DRB3*01/03: colorectal cancer^[11]

Genetic Linkage

Serotypes	DRA	DRB1	DRB3
DR12 Haplotypes
DR11(5)-DR52	*0101	*1201	*0101
	*0101	*1202	*0201
	*0101	*1202	*0202
	*0101	*1202	*0301
Serotypes	DRB1	DQA1	DQB1
DR12(5)-DQ7 (7.5, 3)	*1201	*0505	*0301
DR12(5)-DQ7 (7.5, 3)	*1202	*0505	*0301
DR12(5)-DQ7 (7.3, 3)	*1201	*0303	*0301
DR12(5)-DQ7 (7.4, 3)	*1201	*0401	*0301
DR12(5)-DQ7 (7.6, 3)	*1201	*0601	*0301
Serotypes	HLA-A	HLA-C	HLA-B	DRB1
A31(19)-Cw10-B51(5)-DR12(5)	*3101	*0304	*5101	*1202
A11-Cw9-B75(15)-DR12(5)	*1101	*0303	*1502	*1202
A2-Cw10-B13-DR12(5)	*0201	*0304	*1301	*1202

HLA-DR12 is genetically linked to DR52^[12] and HLA-DQ7 serotypes.

References

^ derived from IMGT/HLA
^ DR8 - 2%
^ Gao X, Barnardo M, Winsey S, Ahmad T, Cook J, Agudelo J, Zhai N, Powell J, Fuggle S, Wojnarowska F (2005). "The association between HLA DR, DQ antigens, and vulval lichen sclerosus in the UK: HLA DRB112 and its associated DRB112/DQB10301/04/09/010 haplotype confers susceptibility to vulval lichen sclerosus, and HLA DRB10301/04 and its associated DRB10301/04/DQB10201/02/03 haplotype protects from vulval lichen sclerosus.". J Invest Dermatol 125 (5): 895-9. PMID 16297186.
^ Liao HT, Lin KC, Chen CH, et al (2007). "Human Leukocyte Antigens in Undifferentiated Spondyloarthritis". doi:10.1016/j.semarthrit.2007.04.004. PMID 17604825.
^ Cerna M, Vavrincova P, Havelka S, Ivaskova E, Stastny P (1994). "Class II alleles in juvenile arthritis in Czech children.". J Rheumatol 21 (1): 159-64. PMID 8151573.
^ Vargas-Alarcon G, Granados J, Bekker C, Alcocer-Varela J, Alarcón-Segovia D (1995). "Association of HLA-DR5 (possibly DRB1*1201) with the primary antiphospholipid syndrome in Mexican patients.". Arthritis Rheum 38 (9): 1340-1. PMID 7575732.
^ Ju LY, Paolozzi L, Delecoeuillerie G, et al (1994). "A possible linkage of HLA-DRB haplotypes with Tiopronin intolerance in rheumatoid arthritis". Clin. Exp. Rheumatol. 12 (3): 249-54. PMID 7915222.
^ Fujii T, Nojima T, Yasuoka H, Satoh S, Nakamura K, Kuwana M, Suwa A, Hirakata M, Mimori T (2001). "Cytokine and immunogenetic profiles in Japanese patients with adult Still's disease. Association with chronic articular disease.". Rheumatology (Oxford) 40 (12): 1398-404. PMID 11752512.
^ Himmunngan P, Sangwatanaroj S, Petmitr S, Viroonudomphol D, Siriyong P, Patmasiriwat P (2006). "HLa-class II (DRB & DQB1) in Thai sudden unexplained death syndrome (Thai SUDS) families (Lai-Tai families)". Southeast Asian J. Trop. Med. Public Health 37 (2): 357-65. PMID 17124999.
^ Tighe M, Hall M, Barbado M, Cardi E, Welsh K, Ciclitira P (1992). "HLA class II alleles associated with celiac disease susceptibility in a southern European population.". Tissue Antigens 40 (2): 90-7. PMID 1357780.
^ Bidwell J, Soong T, Raymond P, Doherty D, Hui K (1992). "HLA genotyping of colorectal carcinoma in the Chinese population.". Hum Immunol 34 (1): 19-23. PMID 1356954.
^ Song EY, Park H, Roh EY, Park MH (2004). "HLA-DRB1 and -DRB3 allele frequencies and haplotypic associations in Koreans". Hum. Immunol. 65 (3): 270-6. doi:10.1016/j.humimm.2003.12.005. PMID 15041167.

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Category: HLA-DR haplotypes

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "HLA-DR12". A list of authors is available in Wikipedia.