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HLA-A66



major histocompatibility complex (human), class I, A66
Alleles A*6601
A*6602
A*6603
Structure (See HLA-A)
Identifiers
6601 6602 6603
Symbol(s) HLA-A
EBI-HLA A*6601
EBI-HLA A*6602
EBI-HLA A*6603
Shared data
Locus chr.6 6p21.31

HLA-A66 (A66) is an HLA-A serotype. The serotype identifies the more common HLA-A*66 gene products. A66 is a split antigen type of the A10 broad antigen type. A*6601 is believed to have been formed by a single gene conversion between another HLA-A and the A*2601 allele.[1] A66 is more common in Africa and SW Europe. A66 is uncommon.


Serotype

A66, A10 serotype recognition of Some HLA A*66 allele-group gene products[2]
A*66 A66 A10 A26 Other Sample
allele % % % % size (N)
6601 20 10 61 3 799
6602 38 10 4 31 205
6603 32 7 7 18 28





A*6601 Frequencies

HLA A*6601 frequencies
freq
ref. Population (%)
[3] Cameroon Sawa7.7
[3] Kenya Luo6.8
[3] Cameroon Sawa7.7
[3] Cameroon Bakola Pygmy5.8
[3] Cameroon Baka Pygmy5.0
[3] Kenya Nandi5.0
[3] Zimbabwe Harare Shona0.2
[3] Cameroon Baka Pygmy5.0
[3] Cameroon Beti4.6
[3] Cameroon Bamileke4.5
[3] India West Bhils4.0
[3] Zimbabwe Harere Shona3.8
[3] Uganda Kampala3.8
[3] India Mumbia Marathas2.5
[3] Cape Verde Northwestern 2.5
[3] Czech republic2.4
[3] Morocco Nador Metalsa2.1
[3] Central Portugal2.0
[3] India West Parsis2.0
[3] South Africian Natal Zulu2.0
[3] Kenya1.7
[3] Tunisia Tunis1.7
[3] Guinea Bissau1.5
[3] Georgia Tibilisi1.4
[3] Zambia Lusaka1.2
[3] Italy Bergamo1.1
[3] Pakistan Karachi Parsi1.1
[3] Oman0.8
[3] Sudanese0.8
[3] Belgium0.5
[3] Southeast France0.4
[3] Mongolia Buriat0.4
[3] Wales0.2
HLA A*6602 frequencies
freq
ref. Population (%)
[3] South Africian Natal Zulu1.5
[3] Cameroon Yaounde1.1
[3] Cameroon Bamileke0.6
[3] Senegal Niokholo Mandenka0.5
[3] Kenya Nandi0.4
[3] Zimbabwe Harare Shona0.2
[3] Wales0.03
HLA A*6603 frequencies
freq
ref. Population (%)
[3] Cameroon Pygmy Baka10.0
[3] Cameroon Bakola Pygmy9.0
[3] Cameroon Sawa7.7
[3] CAR Mbenzele Pygmy2.8
[3] Zimbabwe Harare Shona0.2


References

  1. ^ Madrigal JA, Hildebrand WH, Belich MP, et al (1993). "Structural diversity in the HLA-A10 family of alleles: correlations with serology". Tissue Antigens 41 (2): 72-80. PMID 8475492.
  2. ^ derived from IMGT/HLA
  3. ^ a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac ad ae af ag ah ai aj ak al am an ao ap aq ar as Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens 61 (5): 403-7. PMID 12753660.
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "HLA-A66". A list of authors is available in Wikipedia.
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