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HLA-A26



major histocompatibility complex (human), class I, A26
Alleles A*2601
A*2602
A*2603
A*2605
Structure (See HLA-A)
Identifiers
2601 2602 2603 2605
Symbol(s) HLA-A
EBI-HLA A*2601
EBI-HLA A*2602
EBI-HLA A*2603
EBI-HLA A*2605
Shared data
Locus chr.6 6p21.31

HLA-A26 (A26) is an HLA-A serotype. The serotype identifies the more common HLA-A*26 gene products. A26 is a split antigen of the A10 broad antigen serotype group. A*2601 is believed to be the ancestral type for the A10 group, this group also includes A25, A34, A43 and A66.[1] A26 is broadly distributed but A26 is unusually common in Japan with a number of variants.


Serotype

A26 and A10 serotype recognition of Some HLA A*26 allele-group gene products[1]
A*26 A26 A10 Sample
allele % % size (N)
2601 97 2 1730
2602 81 31
2603 68 8 38
2605 90 10


Serotype recognition of most alleles is generally good.

Disease associations

A26 Serotype is associated with adult T-cell leukemia in Japanese.[2][3]

References

  1. ^ derived from IMGT/HLA
  2. ^ Nomura K, Utsunomiya A, Furushou H, Tara M, Hazeki M, Tokunaga M, Uozumi K, Hanada S, Yashiki S, Tajima K, Sonoda S (2006). "A family predisposition to adult T-cell leukemia.". J Clin Exp Hematop 46 (2): 67-71. PMID 17142956.
  3. ^ Yashiki S, Fujiyoshi T, Arima N, Osame M, Yoshinaga M, Nagata Y, Tara M, Nomura K, Utsunomiya A, Hanada S, Tajima K, Sonoda S (2001). "HLA-A*26, HLA-B*4002, HLA-B*4006, and HLA-B*4801 alleles predispose to adult T cell leukemia: the limited recognition of HTLV type 1 tax peptide anchor motifs and epitopes to generate anti-HTLV type 1 tax CD8(+) cytotoxic T lymphocytes.". AIDS Res Hum Retroviruses 17 (11): 1047-61. PMID 11485622.
v • d • e
HLA-A Serotypes
HLA-A - A1 - A2 - A3 - A9 (A23 - A24) - A10 (A25 - A26 - A34 - A43 - A66) - A11 - A19 (A29 - A30 - A31 - A32 - A33 - A74) - A28 (A68 - A69) - A36 - A80
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "HLA-A26". A list of authors is available in Wikipedia.
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