Gordon MacPherson

Dr George Gordon MacPherson is Reader in Experimental Pathology, Turnbull Fellow, Tutor in Medicine, and Senior Tutor at Oriel College, Oxford. He holds a Bachelor's degree (B.M.), Master's degree (M.A.) and a doctorate (D.Phil.). His research interests lie in Cell Biology, Pathology, and Immunology. Medically qualified, he researches immunology at the Sir William Dunn School of Pathology, University of Oxford.

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He is recognized for his "pioneering work"^[1] on the modulation of the adaptive immune response by sub-populations of antigen-presenting dendritic cells, including a sub-population of dendritic cells which presents self-antigens derived from apoptotic gastrointestinal epithelial cells and helps maintain self-tolerance.^[2] This contrasts with the role of other dendritic cells in presenting pathogen-derived antigens in order to activate specific anti-pathogen T-cell and B-cell responses. He has also been a member of a British study group determining novel breast cancer susceptibility loci.^[3].

Publications

His ten most cited publications are:

• Huang, F.-P., Platt, N., Wykes, M., Major, J.R., Powell, T.J., Jenkins, C.D., MacPherson, G.G. "A discrete subpopulation of dendritic cells transports apoptotic intestinal epithelial cells to T cell areas of mesenteric lymph nodes" (2000) Journal of Experimental Medicine, 191 (3), pp. 435-443. Cited 427 times.

• MacPherson, G.G., Warrell, M.J., White, N.J. "Human cerebral malaria. A quantitative ultrastructural analysis of parasitized erythrocyte sequestration. (1985) American Journal of Pathology, 119 (3), pp. 385-401. Cited 279 times.

• Damoisequx, J.G.M.C., Dopp, E.A., Calame, W., Chao, D., MacPherson, G.G., Dijkstra, C.D. "Rat macrophage lysosomal membrane antigen recognized by monoclonal antibody ED1. (1994) Immunology, 83 (1), pp. 140-147. Cited 250 times.

• Liu, L.M., MacPherson, G.G. "Antigen acquisition by dendritic cells: Intestinal dendritic cells acquire antigen administered orally and can prime naive T cells in vivo." (1993) Journal of Experimental Medicine, 177 (5), pp. 1299-1307. Cited 176 times.

• Wykes, M., Pombo, A., Jenkins, C., MacPherson, G.G. "Dendritic cells interact directly with naive B lymphocytes to transfer antigen and initiate class switching in a primary T-dependent response" (1998) Journal of Immunology, 161 (3), pp. 1313-1319. Cited 146 times.

• MacPherson, G.G., Jenkins, C.D., Stein, M.J., Edwards, C. Endotoxin-mediated dendritic cell release from the intestine: Characterization of released dendritic cells and TNF dependence" (1995) Journal of Immunology, 154 (3), pp. 1317-1322. Cited 145 times.

• Hume, D.A., Robinson, A.P., MacPherson, G.G., Gordon, S."The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80. Relationship between macrophages, Lagerhans cells, reticular cells, and dendritic cells in lymphoid and hematopoietic organs" (1983) Journal of Experimental Medicine, 158 (5), pp. 1522-1536. Cited 116 times.

• Pugh, C.W., MacPherson, G.G., Steer, H.W. Characterization of nonlymphoid cells derived from rat peripheral lymph (1983) Journal of Experimental Medicine, 157 (6), pp. 1758-1779. Cited 99 times.

• Huang, F.-P., Farquhar, C.F., Mabbott, N.A., Bruce, M.E., MacPherson, G.G. Migrating intestinal dendritic cells transport PrPSc from the gut (2002) Journal of General Virology, 83 (1), pp. 267-271. Cited 77 times.

• Liu, L., Zhang, M., Jenkins, C., MacPherson, G.G. "Dendritic cell heterogeneity in vivo: Two functionally different dendritic cell populations in rat intestinal lymph can be distinguished by CD4 expression" (1998) Journal of Immunology, 161 (3), pp. 1146-1155. Cited 72 times.

References

1. ^ Iwasaki,A., "Mucosal dendritic cells" Annual Review of Immunology (2007). 25:381–418 url=[1] "Pioneering work on LP DCs by G. MacPherson and colleagues analyzed DCs [dendritic cells] in the lymph that were bound for the MLNs (mesenteric lymph nodes)."
2. ^ Huang, F.-P., Platt, N., Wykes, M., Major, J.R., Powell, T.J., Jenkins, C.D., MacPherson, G.G. "A discrete subpopulation of dendritic cells transports apoptotic intestinal epithelial cells to T cell areas of mesenteric lymph nodes" (2000) Journal of Experimental Medicine, 191 (3), pp. 435-443.
3. ^ "Genome-wide association study identifies novel breast cancer susceptibility loci." Nature. 2007 May 27 PMID: 17529967