Gangrene

Gangrene is a complication of necrosis (i.e., cell death) characterized by the decay of body tissues, which become black and malodorous. It is caused by infection or ischemia, such as from thrombosis (blocked blood vessel). It is usually the result of critically insufficient blood supply (e.g., peripheral vascular disease) and is often associated with diabetes and long-term smoking. This condition is most common in the lower extremities. The best treatment for gangrene is revascularization (i.e., restoration of blood flow) of the affected organ, which can reverse some of the effects of necrosis and allow healing. Other treatments include auto-amputation, debridement and local care, or surgical amputation. The method of treatment is generally determined depending on location of affected tissue and extent of tissue loss.

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Etymology

The etymology of gangrene derives from the Latin word "gangraena" and from the Greek gangraina (γάγγραινα), which means "putrefaction of tissues".

History

As early as 1028, when antibiotics had not yet been invented, fly maggots were commonly used to treat chronic wounds or ulcers to prevent or arrest necrotic spread, as some species of maggots consume only dead flesh, leaving nearby living tissue unaffected. This practice largely died out after the introduction of antibiotics and enzyme to the range of treatments for wounds. Recently, however, maggot therapy has regained some credibility and is sometimes employed with great efficacy in cases of chronic tissue necrosis.

Types of gangrene

Dry gangrene

  Dry gangrene begins at the distal part of the limb due to ischemia and often occurs in the toes and feet of elderly patients due to arteriosclerosis. Gangrene spreads slowly until it reaches the point where the blood supply is adequate to keep tissue viable. Macroscopically, the affected part is dry, shrunken and dark black, resembling the foot of a mummy. The dark colouration is due to liberation of hemoglobin from hemolyzed red blood cells which is acted upon by hydrogen disulphide (HG) produced by the bacteria, resulting in formation of black iron sulphide that remains in the tissues. The line of separation usually brings about complete separation with eventual falling off of the gangrenous tissue if it is not removed surgically.

If the blood flow is interrupted for a reason other than severe bacterial infection, the result is a case of dry gangrene. People with impaired peripheral blood flow, such as diabetics, are at greater risk of contracting dry gangrene.

The early signs of dry gangrene are a dull ache and sensation of coldness in the affected area along with pallor of the flesh. If caught early, the process can sometimes be reversed by vascular surgery. However, if necrosis sets in, the affected tissue must be removed just as with wet gangrene.

Internal gangrene

Internal gangrene (also called "white gangrene") is marked by bleaching of internal tissue: The site of gangrene is located inside the body, and is usually contracted after surgery or trauma.

Wet gangrene

  Wet gangrene occurs in naturally moist tissue and organs such as the mouth, bowel, lungs, cervix, and vulva. Bedsores occurring on body parts such as the sacrum, buttocks and heels -although not necessarily moist areas - are also categorized as wet gangrene infections. In wet gangrene, the tissue is infected by saprogenic microorganisms (Bac.perfringes, fusiformis, putrificans, etc.), which cause tissue to swell and emit a fetid smell. Wet gangrene usually develops rapidly due to blockage of venous and/or arterial blood flow. The affected part is saturated with stagnant blood which promotes the rapid growth of bacteria. The toxic products formed by bacteria are absorbed causing systemic manifestation of septicemia and finally death. Macroscopically, the affected part is edematous, soft, putrid, rotten and dark. The darkness in wet gangrene occurs due to the same mechanism as in dry gangrene.

Gas gangrene

Main article: Gas gangrene

Gas gangrene is a bacterial infection that produces gas within tissues. It is a deadly form of gangrene usually caused by Clostridium perfringens bacteria. Infection spreads rapidly as the gases produced by bacteria expand and infiltrate healthy tissue in the vicinity. Because of its ability to quickly spread to surrounding tissues, gas gangrene should be treated as a medical emergency.

Gas gangrene is caused by exotoxin-producing clostridial species, which are mostly found in soil and other anaerobes (e.g. Bacteroides and anaerobic streptococci). These environmental bacteria may enter the muscle through a wound and subsequently proliferate in necrotic tissue and secrete powerful toxins. These toxins destroy nearby tissue, generating gas at the same time. A gas composition of 5.9% hydrogen, 3.4% carbon dioxide, 74.5% nitrogen and 16.1% oxygen was reported in one clinical case.^[1]

Gas gangrene can cause myonecrosis, gas production, and sepsis. Progression to toxemia and shock is often very rapid.

Specific gangrenes

• Noma is a gangrene of the face.
• Necrotizing fasciitis affects the deeper layers of the skin.
• Fournier gangrene usually affects the male genitals.

Treatment

Treatment is usually surgical debridement and excision with amputation is necessary in many cases. Antibiotics alone are not effective because they do not penetrate ischemic muscles sufficiently. However, penicillin is given as an adjuvant treatment to surgery. In addition to surgery and antibiotics, Hyperbaric oxygen therapy (HBOT) is used to inhibit the growth of and kill the anaerobic C. perfringens.

See also

• Wound healing
• Liquefactive necrosis
• Bedsore

References

1. ^ Chi CH, Chen KW, Huang JJ, Chuang YC, Wu MH. Gas composition in Clostridium septicum gas gangrene. Journal of the Formosan Medical Association, Vol 94, 12, 1995 Dec, Pages 757-9.