My watch list

Gallamine


Gallamine
Systematic (IUPAC) name
N-[2-[2,3-bis (2-diethylaminoethoxy) phenoxy]ethyl]- N-ethyl-ethanamine
Identifiers
CAS number	65-29-2
ATC code	M03AC02
PubChem	67425
DrugBank	APRD00712
Chemical data
Formula	C₂₄H₄₅N₃O₃ C₃₀H₆₀N₃O₃⁺³ · 3 I^- (gallamine triethiodide)
Mol. mass	423.633 g/mol 891.529 g/mol (triethiodide)
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Gallamine (as gallamine triethiodide) is a non-depolarising muscle relaxant. It acts by combining with the cholinergic receptor sites in muscle and competitively blocking the transmitter action of acetylcholine. Gallamine has a parasympatholytic effect on the cardiac vagus nerve which causes tachycardia and occasionally hypertension. Very high doses cause histamine release.

Additional recommended knowledge

Weighing the right way

Essential Laboratory Skills Guide

How to ensure accurate weighing results every day?

Gallamine is commonly used to stabilize muscle contractions during surgical procedures.

v • d • e Muscle relaxants (M03)
Peripherally acting (primarily antinicotinic, neuromuscular-blocking drugs)	curare alkaloids (Alcuronium, Dimethyltubocurarine, Tubocurarine) - choline derivatives (Suxamethonium) - other quaternary ammonium compounds (Atracurium, Cisatracurium, Doxacurium chloride, Fazadinium bromide, Gallamine, Hexafluronium, Mivacurium chloride, Pancuronium, Pipecuronium bromide, Rocuronium bromide, Vecuronium) - other (Botulinum toxin)
Centrally acting	carbamic acid esters (Phenprobamate, Carisoprodol, Methocarbamol, Styramate, Febarbamate), Baclofen, Chlormezanone, Chlorzoxazone, Cyclobenzaprine, Lorazepam, Mephenesin, Orphenadrine, Phenyramidol, Pridinol, Tetrazepam, Thiocolchicoside, Tizanidine, Tolperisone
Directly acting	Dantrolene