Glycogenphosphorylase isoenzyme BB

Glycogen Phosphorylase BB (GPBB) is an isoenzyme of glycogen phosphorylase. This isoform of the enzyme exists in cardiac (heart) and brain tissue. The enzyme is one of the "new cardiac markers" which are discussed to improve early cardiac diagnosis in ACS. Further members of this enzyme family are GPLL (liver) and GPMM (muscle).

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This enzyme GPBB can be detected in heart infarctions as an early cardiac marker of ACS (acute coronary syndromes). Other enzymes related to glycogen phosphorylase are abbreviated as GPLL (liver) and GPMM (muscle).

Literature

• Fred Apple at al. Future Biomarkers for Detection of Ischemia and Risk Stratification in Acute Coronary Syndrome[1]
• Dirk Peetz et al., Glycogen phosphorylase BB in acute coronary syndromes. Clin Chem Lab Med. 2005 ;43 (12):1351-8 16309372 [2]