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G12/G13



guanine nucleotide binding protein (G protein) alpha 12
Identifiers
Symbol GNA12
Entrez 2768
HUGO 4380
OMIM 604394
RefSeq NM_007353
UniProt Q03113
Other data
Locus Chr. 7 p22.3
guanine nucleotide binding protein (G protein), alpha 13
Identifiers
Symbol GNA13
Entrez 10672
HUGO 4381
OMIM 604406
RefSeq NM_006572
UniProt Q14344
Other data
Locus Chr. 17 q24

G12/G13 subunits are alpha units of heterotrimeric G proteins which regulate cell process through the use of guanine nucleotide exchange factors.

They are not sensitive to pertussis toxin.[1]

Genes

  • GNA12, GNA13

References

  1. ^ Harhammer R, Nürnberg B, Harteneck C, Leopoldt D, Exner T, Schultz G (1996). "Distinct biochemical properties of the native members of the G12 G-protein subfamily. Characterization of G alpha 12 purified from rat brain". Biochem. J. 319 ( Pt 1): 165-71. PMID 8870664.
  • Dhanasekaran N., Dermott J.M. (1996). "Signaling by the G12 class of G proteins.". 'Cell. Sibnal.' 8: 235-45. PMID: 8842523 [1].
  • Wang D, Tan YC, Kreitzer GE, Nakai Y, Shan D, Zheng Y, Huang XY. (2006). "G proteins G12 and G13 control the dynamic turnover of growth factor-induced dorsal ruffles.". ' J Biol Chem.' 281: 32660-7. PMID: 16943201 [2].
  • Shan D, Chen L, Wang D, Tan YC, Gu JL, Huang XY (2006). "The G protein G alpha(13) is required for growth factor-induced cell migration.". 'Dev. Cell.' 10: 707-18. PMID: 16740474 [3].
  • MeSH GTP-Binding+Protein+alpha+Subunits,+G12-G13
v • d • e
Acid anhydride hydrolases: GTPases/G proteins (EC 3.6.5)
3.6.5.1: Heterotrimeric G proteinGαs - Gαi - Gαq/11 - Gα12/13 - Transducin
3.6.5.2: Small GTPaseRas - Rab (Rab27) - Arf (Arf6) - Ran - Rheb - Rho (RhoA, RhoB, CDC42, Rac1) - Rap
3.6.5.3: Elongation factorProkaryotic - Eukaryotic
3.6.5.5-6: OtherDynamin (is a GTPase, is not a G protein) - Tubulin
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "G12/G13". A list of authors is available in Wikipedia.
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