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Fumarate reductase



Fumarate reductase respiratory complex
Identifiers
Symbol Fum_red_TM
Pfam PF02967
InterPro IPR004224
SCOP 1qla
OPM family 3
OPM protein 2bs3
Available PDB structures:

1qlaF:1-243 2bs3F:1-243 1qlbC:1-243 2bs4F:1-243

Fumarate reductase is the enzyme that converts fumarate to succinate, it is important in microbial metabolism as a means for anaerobic respiration.[1]

Succinate + acceptor <=> fumarate + reduced acceptor

In other words, fumarate reductase couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, in a reaction opposite to that catalysed by the related complex II of the respiratory chain (succinate dehydrogenase)[2].

Fumarate reductase complex includes three subunits. Subunit A contains the site of fumarate reduction and a covalently bound flavin adenine dinucleotide prosthetic group. Subunit B contains three iron-sulphur centres. The menaquinol-oxidizing subunit C consists of five membrane-spanning, primarily helical segments and binds two haem b molecules[2].

See also

References

  1. ^ Iverson TM, Luna-Chavez C, Cecchini G, Rees DC (1999). "Structure of the Escherichia coli fumarate reductase respiratory complex". Science 284 (5422): 1961-6. PMID 10373108.
  2. ^ a b Michel H, Lancaster CR, Kroger A, Auer M (1999). "Structure of fumarate reductase from Wolinella succinogenes at 2.2 A resolution". Nature 402 (6760): 377-385. PMID 10586875.
v • d • e
Oxidoreductases: CH-CH oxidoreductases (EC 1.3)
1.3.1. NAD/NADP acceptorEnoyl-acyl carrier protein reductase/Enoyl ACP reductase - 7-Dehydrocholesterol reductase - Biliverdin reductase - 2,4 Dienoyl-CoA reductase
1.3.3. Oxygen acceptorDihydroorotate dehydrogenase - Coproporphyrinogen III oxidase - Protoporphyrinogen oxidase -
1.3.5. QuinoneSuccinate - coenzyme Q reductase
1.3.99. Other acceptorsFumarate reductase - Butyryl CoA dehydrogenase - Acyl CoA dehydrogenase - 5-alpha reductase - Glutaryl-CoA dehydrogenase - Isovaleryl coenzyme A dehydrogenase

This article includes text from the public domain Pfam and InterPro IPR004224

 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Fumarate_reductase". A list of authors is available in Wikipedia.
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