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Fox-Fordyce disease

**Fox-Fordyce disease**
*Classification & external resources*
ICD-10	L75.2
ICD-9	705.82
DiseasesDB	30029
eMedicine	derm/160
MeSH	D005588

Fox-Fordyce disease is a chronic blockage of the sweat gland ducts with a secondary, nonbacterial inflammatory response to the secretions and cellular debris in the cysts. Hidradenitis is very similar but tends to have a secondary bacterial infection so that pus-draining sinuses are formed. It is a very devastating skin disease that does not have universally curative treatments.

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Eponym

It is named for George Henry Fox and John Fordyce.^[1]^[2]

Treatment

The mainstay treatment is surgical removal of the skin tissue containing affected sweat glands. Irradiation therapy may also be used and antibiotics are used to reduce the inflammatory response.

No treatment is required for Fordyce granules, except for cosmetic removal of labial lesions. Inflamed glands can be treated topically with clindamycin. When surgically excised, recurrence does not occur. Neoplastic transformation is very rare but has been reported.

References

^ synd/1512 at Who Named It
^ G. H. Fox, J. A. Fordyce. Two cases of a rare papular disease affecting the axillary region. Journal of Cutaneous and Genitourinary Diseases, Chicago, 1902, 20: 1-5.

v • d • e Diseases of the skin and subcutaneous tissue (integumentary system) (L, 680-709)
Infections	Staphylococcus (Staphylococcal scalded skin syndrome, Impetigo, Boil, Carbuncle) - Cellulitis (Paronychia) - Acute lymphadenitis - Pilonidal cyst - Corynebacterium (Erythrasma)
Bullous disorders	Pemphigus - Pemphigoid (Bullous pemphigoid) - Dermatitis herpetiformis
Dermatitis and eczema	Atopic dermatitis - Seborrhoeic dermatitis (Dandruff, Cradle cap) - Diaper rash - Urushiol-induced contact dermatitis - Contact dermatitis - Erythroderma - Lichen simplex chronicus - Prurigo nodularis - Itch - Pruritus ani - Nummular dermatitis - Dyshidrosis - Pityriasis alba
Papulosquamous disorders	Psoriasis (Psoriatic arthritis) - Parapsoriasis (Pityriasis lichenoides et varioliformis acuta, Pityriasis lichenoides chronica) - Pityriasis rosea - Lichen planus - Pityriasis rubra pilaris - Lichen nitidus
Urticaria and erythema	Urticaria (Dermatographic urticaria, Cholinergic urticaria) - Erythema (Erythema multiforme, Stevens-Johnson syndrome, Toxic epidermal necrolysis, Erythema nodosum, Erythema annulare centrifugum, Erythema marginatum)
Radiation-related disorders	Sunburn - Actinic keratosis - Polymorphous light eruption - Radiodermatitis - Erythema ab igne
Disorders of skin appendages	nail disease: Ingrown nail - Onychogryposis - Beau's lines - Yellow nail syndrome hair loss: Alopecia areata (Alopecia totalis, Alopecia universalis, Ophiasis) - Androgenic alopecia - Telogen effluvium - Traction alopecia - Lichen planopilaris - Trichorrhexis nodosa other follicular disorders: Hypertrichosis (Hirsutism) - Acne vulgaris - Rosacea (Perioral dermatitis, Rhinophyma) - follicular cysts (Epidermoid cyst, Sebaceous cyst, Steatocystoma multiplex) - Pseudofolliculitis barbae - Hidradenitis suppurativa sweat disorders: eccrine (Miliaria, Anhidrosis) - apocrine (Body odor, Chromhidrosis, Fox-Fordyce disease)
Other	pigmentation (Vitiligo, Melasma, Freckle, Café au lait spot, Lentigo/Liver spot) - Seborrheic keratosis - Acanthosis nigricans - Callus - Pyoderma gangrenosum - Bedsore - Keloid - Granuloma annulare - Necrobiosis lipoidica - Granuloma faciale - Lupus erythematosus - Morphea - Calcinosis cutis - Sclerodactyly - Ainhum - Livedoid vasculitis
see also congenital (Q80-Q84, 757)

Category: Skin diseases

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Fox-Fordyce_disease". A list of authors is available in Wikipedia.