Fibrous dysplasia

Fibrous dysplasia is a disease that causes growths or lesions in one or more bones of the human body.

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These lesions are tumor-like growths that consist of replacement of the medullary bone with fibrous tissue, causing the expansion and weakening of the areas of bone involved. Especially when involving the skull or facial bones, the lesions can cause externally visible deformities. The skull is often, but not necessarily, affected, and any other bone(s) can be involved.

• Many patients have lesions localized in only one bone (monostotic fibrous dysplasia), affecting 70-80%.
• Others have them in many bones (polyostotic fibrous dysplasia).

In 3% of cases, people suffering from fibrous dysplasia also have endocrine diseases and skin pigmentation; the three together constitute McCune-Albright syndrome.

Fibrous dysplasia is very rare, not much is known about it, and there is no known cure. However, it is known that it is caused by a genetic mutation that occurs sometime during fetal development, and is not hereditary.

See also

• Cherubism