Felypressin

Felypressin is added to some local anaesthetics such as prilocaine in a concentration of 0.003 i.u./ml. Felypressin is a non-catecholamine vasoconstrictor that is chemically related to vasopressin, the posterior pituitary hormone. Felypressin is a V1 Agonist, and will thus have affects at all V1 receptors. It will, however, have its main physiological effects on vascular SMC's due to the form in which it is administered.

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V1 receptors are found in various sites around the body. The major points include the CNS, Liver, Anterior Pituitary, Muscle (both vascular and non-vascular smooth muscle), and Platelets (CLAMP).

Another example of a V1 Agonist is Terlipressin - which is used in Oesophageal Varices.

References

• "Vasopressin analogues and treatments", Prof Buckingham, ICSM - adapted by JHPatel