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Federica Sallusto



 

Federica Sallusto (born November 27, 1961) is an Italian biologist. She was born in Naples, Italy. After high school, she studied in the Faculty of Biology at the University of La Sapienza in Rome where she took the degree with honors.

She is currently group leader at the Institute for Research in Biomedicine in Bellinzona, Switzerland and is adjunct professor of immunology at the University of Palermo, Italy.

Contents

Professional Societies

  • Italian Society of Immunology (1989-present).
  • Swiss Society for Allergology and Immunology (2000-present).
  • Member of the Council of the Swiss Society for Allergology and Immunology (2005-present).
  • European Academy of Allergy and Clinical Immunology (2001-present).
  • Member of the Immunology section of the European Academy of Allergy and Clinical Immunology (2001-2005).

Editorial Boards

  • Immunology Letters
  • International Archives of Allergy and Applied Immunology
  • Signal Transduction
  • Journal of Experimental Medicine
  • Human Immunology

Peer Reviewing

  • Ad hoc reviewer for several journals including: Nature, Science, Nature Immunology, Immunity, Journal Experimental Medicine, Blood, Journal of Immunology, European Journal of Immunology.
  • Ad hoc reviewer for several grants agencies including: Swiss National Science Foundation, Wellcome Trust, European Commission, German Science Foundation, Austrian Science Funds, Health Research Council of New Zealand.
  • Panel of expert for Institutional reviewing: INSERM (France), German Science Foundation.

Publications

  • Lanzavecchia A, Sallusto F. Toll like receptors and innate immunity in B cell activation and antibody responses. Curr Opin Immunol 2007, in press.
  • Macagno A, Napolitani G, Lanzavecchia A, Sallusto F. Duration, combination and timing: the signal integration model of dendritic cell activation.Trends Immunol 2007, in press.
  • Barfod L, Bernasconi NL, Dahlbäck M, Jarrossay D, Haste Andersen P, Salanti A, Ofori MF, Turner L, Resende M, Nielsen MA, Theander TG,1 Sallusto F, Lanzavecchia A, Hviid L. Human pregnancy-associated malaria-specific B cells target polymorphic, conformational epitopes in VAR2CSA. Mol Microbiol 2007, 63:335-347.
  • Mackay CR, Sallusto F. A new role for CCR5 in innate immunity - binding to bacterial heat shock protein 70. Eur J Immunol 2006, 36:2293-2295.
  • Lanzavecchia A, Bernasconi N, Traggiai E, Ruprecht CR, Corti D, Sallusto F. Understanding and making use of human memory B cells. Immunol Rev 2006, 211: 303-309.
  • Rasheed AU, Rahn HP, Sallusto F, Lipp M, Muller G. Follicular B helper T cell activity is confined to CXCR5(hi)ICOS(hi) CD4 T cells and is independent of CD57 expression. Eur J Immunol 2006, 36:1892-1903.
  • Macagno A, Molteni M, Rinaldi A, Bertoni F, Lanzavecchia A, Rossetti C, Sallusto F. A cyanobacterial LPS antagonist prevents endotoxin shock and blocks sustained TLR4 stimulation required for cytokine expression. J Exp Med 2006, 203: 1481-1492.
  • Chtanova T, Newton R, Liu SM, Weininger L, Young TR, Silva DG, Bertoni F, Rinaldi A, Chappaz S, Sallusto F, Rolph MS, Mackay CR. Identification of T cell-restricted genes, and signatures for different T cell responses, using a comprehensive collection of microarray datasets. J Immunol 2005,175: 7837-7847.
  • Napolitani G, Rinaldi A, Bertoni F, Sallusto F, Lanzavecchia A. Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells. Nat Immunol 2005, 6: 769-776.
  • Ruprecht CR, Gattorno M, Ferlito F, Gregorio A, Martini A, Lanzavecchia A, Sallusto F. Coexpression of CD25 and CD27 identifies FoxP3 regulatory T cells in inflamed synovia. J Exp Med 2005, 201: 1793-1803.
  • Lanzavecchia A, Sallusto F. Understanding the generation and function of memory T cell subsets. Curr Opin Immunol 2005, 17: 326-332.
  • Casati S, Aeby P, Basketter DA, Cavani A, Gennari A, Gerberick GF, Griem P, Hartung T, Kimber I, Lepoittevin JP, Meade BJ, Pallardy M, Rougier N, Rousset F, Rubinstenn G, Sallusto F, Verheyen GR, Zuang V; The Report and Recommendations of ECVAM Workshop 51. Dendritic cells as a tool for the predictive identification of skin sensitisation hazard. Alter Lab Anim 2005, 33: 47-62.
  • Sallusto F, Reiner SL. Sliding doors in the immune response. Nat Immunol 2005, 1: 10-12.
  • Martin-Fontecha A, Thomsen LL, Brett S, Gerard C, Lipp M, Lanzavecchia A, Sallusto F. Induced recruitment of NK cells to lymph nodes provides IFN-g for Th1 priming. Nat Immunol 2004, 5: 1260-1265.
  • Lanzavecchia A, Sallusto F. Lead and follow: the dance of dendritic cells and T cells. Nat Immunol 2004, 5: 1201-1202.
  • Sallusto F, Mackay CR. Chemoattractants and their receptors in homeostasis and inflammation. Curr Opin Immunol 2004, 16:724-731.
  • Rivino L, Messi M, Jarrossay D, Lanzavecchia A, Sallusto F, Geginat J. Chemokine receptor expression identifies pre- T helper (Th)1, pre-Th2 and nonpolarized cells among human central memory T cells. J Exp Med 2004, 200: 725-735.
  • Sallusto F, Geginat J, Lanzavecchia A. Central memory and effector memory T cells: activation, maintenance and function. Annu Rev Immunol 2004, 22:745-763.
  • Martín-Fontecha A, Sebastiani S, Höpken UE, Uguccioni M, Lipp M, Lanzavecchia A, Sallusto F. Regulation of dendritic cell migration to the draining lymph node: impact on T lymphocyte traffic and priming. J Exp Med 2003, 198:615-621.
  • Geginat J, Lanzavecchia A, Sallusto F. Proliferation and differentiation potential of human CD8+ T-cell subsets in response to antigen or homeostatic cytokines. Blood 2003, 101:4260-4266.
  • Gett A, Sallusto F, Lanzavecchia A, Geginat J. T lymphocyte fitness promoted by signal strength. Nat Immunol 2003, 4:355-360.
  • Langenkamp A, Nagata K, Murphy K, Wu L, Lanzavecchia A, Sallusto F. Kinetics and expression patterns of chemokine receptors in human CD4+ T lymphocytes primed by myeloid or plasmacytoid dendritic cells. Eur J Immunol 2003, 33:474-482.
  • Messi M, Giacchetto I, Nagata K, Lanzavecchia A, Natoli G, Sallusto F. Memory and flexibility of cytokine gene expression as separable properties of human TH1 and TH2 lymphocytes. Nat Immunol 2003, 4:78-86.
  • Lanzavecchia A, Sallusto F. Opinion-decision making in the immune system: Progressive differentiation and selection of the fittest in the immune response. Nat Rev Immunol 2002, 12:982-987.
  • Langenkamp A, Casorati G, Garavaglia C, Dellabona P, Lanzavecchia A, Sallusto F. T cell priming by dendritic cells: thresholds for proliferation, differentiation and death and intraclonal functional diversification. Eur J Immunol 2002, 32:2046-2054.
  • Sallusto F, Lanzavecchia A. The instructive role of dendritic cells on T-cell responses. Arthritis Res 2002, 4 Suppl 3:S127-32.
  • Ghia P, Strola G, Granziero L, Geuna M, Guida G, Sallusto F, Ruffing N, Montagna L, Piccoli P, Chilosi M, Caligaris-Cappio F. Chronic lymphocytic leukemia B Cells are endowed with the capacity to attract CD4+, CD40L+ T cells by producing CCL22. Eur J Immunol 2002, 32:1403-1413.
  • Geginat J, Sallusto F, Lanzavecchia A. Cytokine-driven proliferation and differentiation of human naïve, central memory and effector memory CD4+ T cells. J Exp Med 2001, 194:1711-1719.
  • Jarrossay D, Napolitani G, Colonna M, Sallusto F, Lanzavecchia A. Specialization and complementarity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells. Eur J Immunol 2001, 31:3388-3393.
  • Sallusto F. Origin and migratory property of dendritic cells in the skin. Curr Opin Allergy 2001, 1:441-448.
  • Sallusto F, Lanzavecchia A. Exploring pathways for memory T cell generation. J Clin Invest 2001, 108:805-806.
  • Lanzavecchia A, Sallusto F. Regulation of T cell immunity by dendritic cells. Cell 2001, 106:263-266.
  • Ghia P, Transidico P, Veiga JP, Schaniel C, Sallusto F, Matsushima K, Sallan SE, Rolink AG, Mantovani A, Nadler LM, Cardoso A, Chemoattractants MDC and TARC are secreted by malignant B-cell precursors following CD40 ligation and support the migration of leukemia-specific T cells. Blood 2001, 98:533-540.
  • Lanzavecchia A, Sallusto F. Antigen decoding by T lymphocytes: from synapses to fate determination. Nat Immunol 2001, 2:487-492.
  • Lanzavecchia A, Sallusto F. The instructive role of dendritic cells on T cell responses: lineages, plasticity and kinetics. Curr Opin Immunol 2001, 13:291-298.
  • Zelle-Rieser C, Barsoum AL, Sallusto F, Ramoner R, Rohrer JW, Holtl L, Bartsch G, Coggin JH Jr, Thurnher M. Expression and immunogenicity of oncofetal antigen-immature laminin receptor in human renal cell carcinoma. J Urol 2001, 165:1705-1709.
  • Lantelme E, Mantovani S, Palermo B, Campanelli R, Sallusto F, Giachino C. Kinetics of GATA-3 gene expression in early polarizing and committed human T cells. Immunology 2001, 102:123-130.
  • Breitfeld D, Ohl L, Kremmer E, Ellwart J, Sallusto F, Lipp M, Förster R. Follicular B helper T Cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production. J Exp Med 2000, 192: 1545-1552.
  • Dunbar PR, Smith CL, Chao D, Salio M, Shepherd D, Mirza F, Lipp M, Lanzavecchia A, Sallusto F, Evans A, Russell-Jones R, Harris AL, Cerundolo V. A shift in the phenotype of melan-A-specific CTL identifies melonoma patients with an active tumour-specific immune response. J Immunol 2000, 165: 6644-6652.
  • Sallusto F, Lanzavecchia A. Understanding dendritic cell and T-lymphocyte traffic through the analysis of chemokine receptor expression. Immunol Rev 2000, 177:134-140.
  • Lanzavecchia A, Sallusto F. Dynamics of T cell differentiation: intermediates, effectors and memory cells. Science 2000, 290:92-97.
  • Langenkamp A, Messi M, Lanzavecchia A, Sallusto F. Kinetics of dendritic cell activation: impact on TH1, TH2, and nonpolarized T cells. Nat Immunol 2000, 1:311-316.
  • Gagliardi MC, Sallusto F, Marinaro M, Langenkamp A, Lanzavecchia A, De Magistris MT. Cholera toxin induces maturation of human dendritic cells and licences them for Th2 priming. Eur J Immunol 2000, 30:2394-2403.
  • Sallusto F, Mackay CR, Lanzavecchia A. The role of chemokine receptors in primary, effector and memory immune responses. Annu Rev Immunol 2000, 18:593-620.
  • Sallusto F, Poupot R, Clergue M, De Palma R, Fournie JJ. A flavonoid sulfate antigen activates human ab CD8+ Th2 lymphocytes in pollen allergy. Eur J Immunol 2000, 30:964-968.
  • Lanzavecchia A, Sallusto F. From synapses to immunological memory: the role of sustained T cell stimulation. Curr Opin Immunol 2000, 12:92-98.
  • Macagno A, Gillet M, Khan S, Sallusto F, Lanzavecchia A, Nestlè FO, Groettrup M. Dendritic cells upregulate immunoproteasomes and the proteasome regulator PA28 during maturation. Eur J Immunol 1999, 29:4037-4042.
  • Sallusto F, Lenig D, Förster R, Lipp M, Lanzavecchia A. Two subsets of memory T cells with distinct homing potentials and effector functions. Nature 1999, 401:708-712.
  • Mackay CR, Lanzavecchia A, Sallusto F. Chemoattractant receptors and immune responses. The Immunologists 1999, 7:112-118.
  • Schaniel C, Sallusto F, Ruedl C, Sideras P, Melchers F, Rolink AG. Three chemokines with potential functions in T lymphocyte-independent and -dependent B lymphocyte stimulation. Eur J Immunol 1999, 29:2934-2947.
  • Sallusto F, Kremmer E, Palermo B, Hoy A, Ponath P, Qin S, Förster R, Lipp M, Lanzavecchia A. Switch in chemokine receptor expression upon TCR stimulation reveals novel homing potential for recently activated T cells. Eur J Immunol 1999, 29:2037-2045.
  • Sallusto F, Palermo B, Lenig D, Miettinen D, Matikainen S, Julkunen I, Förster R, Burgstahler R, Lipp M, Lanzavecchia A. Distinct patterns and kinetics of chemokine production regulate dendritic cell function. Eur J Immunol 1999, 29:1617-1625.
  • De Palma R, Wu S, Sallusto F, Di Felice G, Martucci P, Geraci D, Colombo P, Troise C, Sacerdoti G, Nocera A, Gorski J. Use of antagonist peptides to inhibit in vitro T cell responses to Parj1, the major allergen of Parietaria judaica pollen. J Immunol 1999, 162:1982-1987.
  • Sallusto F, Lanzavecchia A. Mobilizing dendritic cells for tolerance, priming and chronic inflammation. J Exp Med 1999, 189:611-614.
  • Sallusto F, Schaerli P, Loetscher P, Schaniel C, Lenig D, Mackay CR, Qin S, Lanzavecchia A. Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation. Eur J Immunol 1998, 28:2760-2769.
  • Sallusto F, Lanzavecchia A, Mackay CR. Role of chemokine receptors in positioning T cells for priming and Th1- or Th2-mediated responses. Immunol Today 1998, 19: 568-574.
  • Schaniel C, Pardali E, Sallusto F, Speletas M, Ruedl C, Shimizu T, Seidl T, Andersson J, Melchers F, Rolink AG, Sideras P. Activated murine B lymphocytes and dendritic cells produce a novel CC chemokine which acts selectively on activated T cells. J Exp Med 1998, 188:451-463.
  • Sallusto F, Lenig D, Mackay CR, Lanzavecchia A. Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes. J Exp Med 1998, 187:875-883.
  • Sallusto F, Mackay CR, Lanzavecchia A. Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells. Science 1997, 277:2005-2007.
  • Corinti S, De Palma R, Fontana A, Gagliardi C, Pini C, Sallusto F. MHC independent recognition of a distinctive pollen antigen, most likely a carbohydrate, by human CD8+ T cells. J Exp Med 1997, 186:899-908.
  • Cella M, Sallusto F, Lanzavecchia A. Origin, maturation and antigen presenting function of dendritic cells. Curr Opinion Immunol 1997, 9:10-16.
  • Nisini R, Paroli M, Accapezzato D, Bonino F, Rosina F, Santantonio T, Sallusto F, Amoroso A, Houghton M, Barnaba, V. Human CD4+ T-cell response to hepatitis delta virus: identification of multiple epitopes and characterization of T-helper cytokine profiles. J Virol 1997, 71:2241-2251.
  • Sallusto F, Nicolò C, De Maria R, Corinti S, Testi R. Ceramide inhibits antigen uptake and presentation by dendritic cells. J Exp Med 1996, 184:2411-2416.
  • Mari A, Di Felice G, Afferni C, Barletta B, Tinghino R, Sallusto F, Pini C. Assessment of skin prik test and serum specific IgE detection in the diagnosis of Cupressaceae pollinosis. J Allergy Clin Immunol 1996, 98:21-31.
  • Sallusto F, Corinti S, Pini C, Biocca MM, Bruno G, Di Felice G. Parietaria-judaica-specific T cell clones in allergic patients: heterogeneity in restriction, Vb usage, and cytokine profile. J Allergy Clin Immunol 1996, 97: 627-637.
  • Sozzani S., Sallusto F., Luini SW, Zhou D, Piemonti L, Allavena P, Van Damme J, Valitutti S, Lanzavecchia A, Mantovani A. Migration of dendritic cells in response to formyl peptides, C5a and a distinct set of chemokines. J Immunol 1995, 155: 3292-3295.
  • Sallusto F, Cella M, Danieli C, Lanzavecchia A. Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products. J Exp Med 1995, 182: 389-400.
  • Di Felice G, Caiaffa MF, Bariletto G, Afferni C, Di Paola R, Mari A, Palumbo S, Tinghino R, Sallusto F, Tursi A, Macchia L, Pini C. Allergens of Arizona cypress (Cupressus arizonica) pollen: characterization of the pollen extract and identification of the allergenic components. J Allergy Clin Immunol 1994, 94: 547-555.
  • Palumbo S, Di Felice G, Mari A, Bonini S, Bruno G, Tinghino R, Afferni C, Sallusto F, Pini C. IgG subclass antibodies to Parietaria judaica pollen extract in normal individuals and allergic subjects. Allergy 1994, 49: 222-229.
  • Sallusto F, Lanzavecchia A. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage-colony stimulating factor plus interleukin 4 and downregulared by tumor necrosis factor-a. J Exp Med 1994, 179: 1109-1118.
  • Dellabona P, Casorati G, Friedli B, Angman L, Sallusto F, Tunnacliffe A, Roosnek E, Lanzavecchia A. In vivo persistence of expanded clones specific for bacterial antigens within the human T cell receptor a/b CD4-8- subset. J Exp Med 1993, 177: 1763-1771.
  • De Cesare F, Pini C, Di Felice G, Caiaffa MF, Macchia L, Tursi A, Tinghino R, Palumbo S, Sallusto F, Federico R. Purification and fine characterization of a major allergen from Olea europaea pollen extract. Allergy 1993, 48: 248-254.
  • Sallusto F, Quintieri F, Pugliese O, Reale G, Pini C, Di Felice G. T-cell and antibody response to Parietaria judaica allergenic fractions in atopic and non-atopic individuals. Allergy 1993, 48: 37-44.
  • Benvenuto R, Bachetoni A, Cinti P, Sallusto F, Franco A, Renna Molajoni E, Barnaba V, Balsano F, Cortesini R. Enhanced production of interferon-g by T lymphocytes cloned from rejected kidney graft. Transplantation 1991, 51: 887-890.
  • Renna Molajoni E, Bachetoni A, Cinti P, Sallusto F, Alfani D, Macchiarelli A, Scibilia G, Cassisi A, Marino B, Cortesini R. Relevance of immunological parameters to detect allograft rejection in heart transplant recipients. Transpl Proc 1989, 21: 2534-2536.
  • Benvenuto R, Bachetoni A, Franco A, Cinti P, Sallusto F, Balsano C, Renna Molajoni E, Barnaba V. Analysis of T lymphocytes cloned from rejected kidney allograft: high frequency of cytotoxic T cell precursors. Int J Immunopathol Pharmacol 1988, 1: 171-176.
  • Renna Molajoni E, Bachetoni A, Cinti P, Pecorella I, Sallusto F, Caricato M, Alfani D, Cortesini R. Phenotypic and functional comparative analysis between infiltrating kidney transplant and peripheral blood immunocompetent cells after allograft nephrectomy. Transpl Proc 1988, 20: 209-210.

Books and Chapters

  • Sallusto F, Lanzavecchia A. The role of dendritic cells in T cell activation and differentiation. In: Handbook of dendritic cells: Biology, Diseases, and Therapies, Lutz MB, Romani N, Steinkasserer A Eds, Wiley-VCH Weinhelm, 2006.
  • Sallusto F, Martin-Fontecha A, Lanzavecchia A. Dendritic cell traffic control by chemokines. In: Chemokine Biology: Basis Research and Clinical Application, Moser B, Letts GL, Neote K Eds, Birkhäuser Verlag Basel, 2006.
  • Messi M. Sallusto F. Chemokine receptor expression in effector and memory T cell subsets. In: Lymphocyte Trafficking in Health and Disease, Badolato R and Silvano S Eds, Birkhäuser Verlag Basel, 2006.
  • Sallusto F, Lanzavecchia A. Chemokine receptors as regulators of dendritic cell and lymphocyte traffic: relevance to autoimmunity. In: The molecular pathology of autoimmune diseases, Theofilopoulos A Ed, G&B Editorial Services, Inc, 2000.
  • Sallusto F, Langenkamp A, Geginat J, Lanzavecchia A. Functional subsets of memory T cells identified by CCR7 expression. In: Curr Top Microbiol Immunol, Melchers F Ed, Springer Verlag 2000, vol. 251, pages 167-171.
  • Sallusto F, Palermo B, Hoy A, Lanzavecchia A. The role of chemokine receptors in directing traffic of naive, type 1 and type 2 T cells. In: Curr Top Microbiol Immunol, Potter M and Melchers F Eds, Springer Verlag 1999, vol. 246, pages 123-128.
  • Schaniel C, Sallusto F, Sideras P, Melchers F, Rolink AG. A novel CC chemokine ABCD-1 produced by dendritic cells and activated B cells, exclusively attracts activated T lymphocytes. In: Curr Topics Microbiol Immunol, Potter M and Melchers F Eds, Springer Verlag 1999, vol. 246, pages 95-101.
  • Cella M, Salio M, Scheidegger D, Engering A, Pieters J, Sallusto F, Lanzavecchia A. Regulation of antigen capture, MHC biosynthesis and degradation optimizes presentation of infectious antigens in maturing dendritic cells. In: Dendritic Cells: Biology and Clinical Applications. Lotze MT and Thomson AW Eds. Academic Press 1999, pages 632-636.

Awards

  • Pharmacia Allergy Research Foundation Award, 1999.

References

  • Institute for Resarch in Biomedicine
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Federica_Sallusto". A list of authors is available in Wikipedia.
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