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FYVE domain


Early endosome antigen 1 (EEA1) dimer with lipids
FYVE zinc finger
Identifiers
Symbol	FYVE
Pfam	PF01363
InterPro	IPR000306
SCOP	1vfy
OPM family	62
OPM protein	1vfy
Available PDB structures: 1dvpA:156-219 1vfyA:168-230 1jocB:1347-1411 1hyjA:1347-1411 1hyiA:1347-1411 1wfkA:2-59 1x4uA:349-411

FYVE zinc finger domain is named after four proteins that it has been found in: Fab1, YOTB/ZK632.12, Vac1, and EEA1.

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The FYVE finger binds two zinc ions. The FYVE finger has eight potential zinc coordinating cysteine positions. Many members of this family also include two histidines in a motif R+HHC+XCG, where + represents a charged residue and X any residue. FYVE domains bind Phosphatidylinositol 3-phosphate.

The FYVE finger is structural similarity to RING domain and PHD finger.

Human proteins containing this domain

ANKFY1; EEA1; FGD1; FGD2; FGD3; FGD4; FGD5; FGD6; FYCO1; HGS; MTMR3; MTMR4; PIP5K3; PLEKHF1; PLEKHF2; RUFY1; RUFY2; WDF3; WDFY1; WDFY2; WDFY3; ZFYVE1; ZFYVE16; ZFYVE19; ZFYVE20; ZFYVE21; ZFYVE26; ZFYVE27; ZFYVE28; ZFYVE9;

References

[1]. Endosomal localization of the autoantigen EEA1 is mediated by a zinc-binding FYVE finger. Stenmark H, Aasland R, Toh BH, D'Arrigo A; J Biol Chem 1996;271:24048-24054. PubMed
[2]. FYVE fingers bind PtdIns(3)P. Gaullier JM, Simonsen A, D'Arrigo A, Bremnes B, Stenmark H, Aasland R; Nature 1998;394:432-433. PubMed
[3]. FYVE-finger proteins - effectors of an inositol lipid. Stenmark H, Aasland R; J Cell Sci 1999;112:4175-4183. PubMed