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Ethotoin


Ethotoin
Systematic (IUPAC) name
3-ethyl-5-phenyl-imidazolidine-2,4-dione
Identifiers
CAS number	86-35-1
ATC code	N03AB01
PubChem	3292
DrugBank	APRD00962
Chemical data
Formula	C₁₁H₁₂N₂O₂
Mol. mass	204.225 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	3 to 9 hours
Excretion	?
Therapeutic considerations
Pregnancy cat.	C
Legal status
Routes	Oral

Ethotoin (marketed as Peganone® by Ovation) is an anticonvulsant drug used in the treatment of epilepsy. It is a hydantoin, similar to phenytoin. Ethotoin lacks phenytoin's side effects of gingival hyperplasia and hirsutism, however it is less effective. This, combined with the need for frequent dosing has limited its usefulness. Ethotoin is no longer widely used.

Additional recommended knowledge

Essential Laboratory Skills Guide

Guide to balance cleaning: 8 simple steps

Mechanism of action

Similar to phenytoin.

Approval history

1957 Peganone was granted Food and Drug Administration (FDA) approval to Abbott Laboratories for treatment of grand mal (tonic clonic) and partial complex (psychomotor) seizures.
2003 Peganone was acquired from Abbott Laboratories by Ovation Pharmaceuticals (specialty pharmaceutical company who acquire underpromoted branded pharmaceutical products).

Indications and usage

Ethotoin is indicated for tonic-clonic and partial complex seizures.

Dosing

Ethotoin is available in 250mg tablets. It is taken orally in 4 to 6 divided doses per day, preferably after food.

Side effects

Ataxia, visual disturbances, rash and gastrointestinal problems.

References

Peganone, a new antiepileptic drug.

Dis Nerv Syst. 1956 May;17(5):155-8.

Schwade ED, Richards RK, Everett GM. PMID 13317788

The Treatment of Epilepsy edited by S. D. Shorvon, David R. Fish, Emilio Perucca, W. Edwin Dodson. Blackwell Publishing. 2004. ISBN 0-632-06046-8
Drugs.com: Ethotoin
PEGANONE® 250 mg Ethotoin Tablets, USP (PDF)

v • d • e Anticonvulsants (N03)
Barbiturates	Barbexaclone, Metharbital, Methylphenobarbital, Pentobarbital, Phenobarbital, Primidone
Hydantoins	Ethotoin, Fosphenytoin, Mephenytoin, Phenytoin
Oxazolidinediones	Ethadione, Paramethadione, Trimethadione
Succinimides	Ethosuximide, Mesuximide, Phensuximide
Benzodiazepines	Clobazam, Clonazepam, Clorazepate, Diazepam, Lorazepam, Midazolam, Nitrazepam, Temazepam
Carboxamides	Carbamazepine, Oxcarbazepine, Rufinamide
Fatty acid derivatives	Valpromide, Valnoctamide
Carboxylic acids	Valproic acid (Sodium valproate & Valproate semisodium), Tiagabine
Others	GABA analogs: Gabapentin, Pregabalin, Progabide, Vigabatrin -- Monosaccharides: Topiramate -- Aromatic allylic alcohols: Stiripentol -- Ureas: Phenacemide, Pheneturide -- Phenyltriazines: Lamotrigine Carbamates: Emylcamate, Felbamate, Meprobamate -- Pyrrolidines: Brivaracetam, Levetiracetam, Nefiracetam, Seletracetam Sulfa drugs: Acetazolamide, Ethoxzolamide, Sultiame, Zonisamide -- Propionates: Beclamide -- Aldehydes: Paraldehyde -- Bromides: Potassium bromide, Sodium bromide

Category: Anticonvulsants

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Ethotoin". A list of authors is available in Wikipedia.