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Epoxide hydrolase



epoxide hydrolase 1, microsomal (xenobiotic)
Identifiers
Symbol EPHX1
Alt. Symbols EPHX
Entrez 2052
HUGO 3401
OMIM 132810
RefSeq NM_000120
UniProt P07099
Other data
EC number 3.3.2.3
Locus Chr. 1 q42.1
epoxide hydrolase 2, cytoplasmic
Identifiers
Symbol EPHX2
Entrez 2053
HUGO 3402
OMIM 132811
RefSeq NM_001979
UniProt P34913
Other data
Locus Chr. 8 p21

Epoxide hydrolase (also known as Epoxide hydratase) functions in detoxication during drug metabolism. It converts epoxides from the degradation of aromatic compounds to trans-dihydrodiols which can be conjugated and excreted from the body.

Epoxides are significant as cytochrome P450 oxidase metabolites of unsaturated carbon-carbon bonds, but are also mutagenic. Epoxide hydrolase is present in large quantity on endoplasmic reticulum.

v • d • e
Ether bond hydrolases (EC 3.3)
Adenosylhomocysteinase - Epoxide hydrolase - Leukotriene A4 hydrolase
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Epoxide_hydrolase". A list of authors is available in Wikipedia.
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