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Epibatidine
Epibatidine is an alkaloid that originally is found in the skin of a neotropical poisonous frog, Epipedobates tricolor, found in modern Ecuador. It was initially isolated by John Daly at the National Institutes of Health, and was found to be a powerful analgesic, about 200 times more potent than morphine.[1] Because the natural source of epibatidine can only supply a small quantity, several laboratory syntheses have been developed.[2] Additional recommended knowledgeInterestingly, the compound is not an opioid; instead, it is similar to nicotine and appears to act by binding and activating nicotinic acetylcholine receptors. While epibatidine may be too toxic to use in clinical practice, the compound represents a new lead in the drug design of new analgesics.[3] References
Categories: Alkaloids | Analgesics | Halogen-containing alkaloids |
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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Epibatidine". A list of authors is available in Wikipedia. |