Elvin A. Kabat

Elvin Abraham Kabat (September 1, 1914–June 16, 2000) was an American biomedical scientist who is considered one of the founding fathers of modern quantitative immunochemistry together with his mentor Michael Heidelberger.In 1977, Kabet and Heidelberger were awarded the Louisa Gross Horwitz Prize from Columbia University.

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Work

Elvin Kabat was engaged in the discovery of the structural and genetic basis for the remarkable specificity of antibodies. Kabat first demonstrated that antibodies are gamma globulins. He characterized the size and stunning heterogeneity of antibody-combining sites. Kabat and his coworkers determined the structures of the major blood group antigens, the embryonic-stage-specific carbohydrate antigens and the carbohydrate markers of leukocyte (white blood cell).

Kabat's work was basic research with many applications to clinical medicine. It greatly advanced our knowledge of inflammation, autoimmunity, and blood transfusion medicine.

Life

Kabat’s parents arrived in the United States from Eastern Europe toward the end of the 19th century. (The family changed their last name from Kabatchnick to Kabat.) Elvin began high school in New York at the age of 12 and completed it in three years. He started at City College of New York at the age of 15 and graduated in 1932 with a major in chemistry at age 18. In January 1933, Kabat was already working in Michael Heidelberger’s laboratory doing routine lab chores at Columbia University’s College of Physicians and Surgeons. Kabat started work on his Ph.D. in the Department of Biochemistry, taking most courses at night, and completed his Ph.D. under Heidelberger in only four years.

Kabat did postdoctoral work with Arne Tiselius and Kai Pederson in Uppsala, Sweden, to learn the new methods of ultracentrifugation and electrophoresis. He returned to New York City to take up a position at Cornell University Medical College. He moved uptown and spent the main part of his career at Columbia University.

In 1942 Kabat married Sally Lennick, a young Canadian art student. They had three sons: Jonathan, Geoffrey, and David.

Sources

• Elvin A. Kabat: September 1, 1914–June 16, 2000, an excellent Biographical Memoir, written by Rose G. Mage and Ten Feizi, published by the US National Academy of Sciences
• Elvin A. Kabat Memorial Symposium with
  • Obituary: Elvin A. Kabat, reprinted from the journal Nature
  • In Memoriam Elvin Abraham Kabat, reprinted from the Journal of Immunology
  • Elvin A. Kabat at 85, obituary in the Boston Globe (he summered at Woods Hole for about 50 years)
  • An Appreciation of Elvin A. Kabat, reprinted from Glycoconjugate Journal
  • Elvin Kabat's Curriculum Vitae
  • Photos of Elvin Kabat