Elastography

Elastography is a non-invasive method in which stiffness or strain images of soft tissue are used to detect or classify tumors. A tumor or a suspicious cancerous growth is normally 5-28 times stiffer than the background of normal soft tissue. When a mechanical compression or vibration is applied, the tumor deforms less than the surrounding tissue. i.e. the strain in the tumor is less than the surrounding tissue.

Additional recommended knowledge

How to quickly check pipettes?

Essential Laboratory Skills Guide

Daily Sensitivity Test

Medical Imaging

Ultrasonic imaging is the most common medical imaging technique for producing elastograms. Some research has been conducted using MRI (magnetic resonance elastography) and computed tomography. However, using ultrasound has the advantages of being cheaper and faster than MRI techniques.

Transient elastography is used for example to measure the stiffness of the liver in vivo (FibroScan, Echosens, France). It is an alternative noninvasive method to liver biopsy. A correlation between liver elasticity and the fibrosis score (or cirrhosis) has been shown.^[1]

Mathematical Description

Pre-compression images are correlated to post-compression images, resulting in regions of large and small change in position. This is called the shift-diagram. The derivative of the shift will produce the strain diagram.

References

1. ^ Ganne-Carrié N, Ziol M, de Ledinghen V, et al (2006). "Accuracy of liver stiffness measurement for the diagnosis of cirrhosis in patients with chronic liver diseases". Hepatology 44 (6): 1511-7. doi:10.1002/hep.21420. PMID 17133503.

External links

• University of Texas Elastography Research
• Mayo Clinic Magnetic Resonance Elastography Research
• Supersonic Imagine
• Echosens
• Press release of potential uses of techniques developed by Dr. Bamber's elastography team at the Institute of Cancer Research in Sutton, UK
• Siemens Medical
• http://www.emodeonline.com
• http://www.hitachimed.com/specifications.asp?ID=1061#1699