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EKLF
Erythroid Krüppel-like Factor (EKLF) is a transcription factor that is necessary for the proper maturation of erythroid (red blood) cells. The molecule has two domains; the transactivation domain and the chromatin-remodeling domain. The carboxyl (C) terminal is composed of three C2H2 zinc fingers that binds to DNA, and the amino (N) terminus is proline rich and acidic [1]. The gene for EKLF is on the human chromosome 19 and on mouse chromosome 8. Additional recommended knowledge
1.Chromatin remodeling 2.Modulation of the gamma to beta globin switch 3.Transcriptional activation
References1. Brown R, Pattison S, van Ree J, Coghill E, Perkins A, Jane S, Cunningham J. Distinct Domains of Erythroid Krüppel-Like Factor Modulate Chromatin Remodeling and Transactivation at the Endogenous β-Globin Gene Promoter. Mol. Cell Biol. 22:7306, 2002. 2. Cooley's Anemia Foundation. About Thalassemia [Internet]. New York, NY: Cooley's Anemia Foundation National Office; 2001 [1 August 2007] . Available from: http://cooleysanemia.org/sections.php?sec=1&tab=8. 3. Hodge D, Coghill E, Keys J, Maguire T, Hartmann B, McDowall A, Weiss M, Grimmond S, Perkins A. A global role for EKLF in definitive and primitive erythropoesis. Blood. 2006 15 April 2006;107(8):3359-70. 4. Perkins A, Sharpe A, Orkin S. Lethal beta-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF. Nature. 375:318, 1995. 5. Tewari R, Gillemans N, Wijgerde M, Nuez B, von Lindern M, Grosveld F, Philipsen S. Erythroid Ekuppel-like Factor is active in primitive and deifinitve erythroidd cells and is required for the function of 5' HS3 of the β globin locus control region. EMBO J. 17:2334, 1998. |
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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "EKLF". A list of authors is available in Wikipedia. |