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Doublecortin
Doublecortin (DCX) is a microtubule-associated protein expressed almost exclusively in immature neurons. Neuronal precursors begin to express DCX shortly after exiting the cell cycle, and continue to express DCX for 2-3 weeks as the cells mature into neurons. Downregulation of DCX begins after 2 weeks, and occurs at the same time that these cells begin to express, a marker for mature neurons.[1] Additional recommended knowledgeDue to the nearly exclusive expression of DCX in developing neurons, this protein has been used increasingly as a marker for neurogenesis. Indeed, the levels of DCX expression increase in response to exercise,[2] which occurs in parallel with increased BrdU labelling, currently a "gold standard" in measuring neurogenesis. See alsoReferences
Categories: Genes on chromosome X | Proteins |
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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Doublecortin". A list of authors is available in Wikipedia. |