Diglyceride acyltransferase

diacylglycerol O-acyltransferase homolog 1 (mouse)
Identifiers
Symbol	DGAT1
Entrez	8694
HUGO	2843
OMIM	604900
RefSeq	NM_012079
UniProt	O75907
Other data
EC number	2.3.1.20
Locus	Chr. 8 q24.3

diacylglycerol O-acyltransferase homolog 2 (mouse)
Identifiers
Symbol	DGAT2
Entrez	84649
HUGO	16940
OMIM	606983
RefSeq	NM_032564
UniProt	Q96PD7
Other data
Locus	Chr. 11 q13.3

Diglyceride acyltransferase (or O-acyltransferase), DGAT, catalyzes the formation of triglycerides from diacylglycerol and Acyl-CoA. There are two isoforms of DGAT encoded by the genes DGAT1 and DGAT2. DGAT is considered the terminal and only committed step in triglyceride synthesis and to be essential for the formation of adipose tissue.^[1] A number of pharmaceutical companies currently have DGAT-1 inhibitors in clinical trials for the treatment of obesity.^[2]

References

^ Cases S, Smith SJ, Zheng YW, Myers HM, Lear SR, Sande E, Novak S, Collins C, Welch CB, Lusis AJ, Erickson SK, Farese RV (1998). "Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis". Proc. Natl. Acad. Sci. U.S.A. 95 (22): 13018-23. PMID 9789033.
^ Pfizer, Bristol finalize deal on metabolic drugs. Retrieved on 2007-08-27.

Categories: Genes on chromosome 8 | Genes on chromosome 11