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Diethyltryptamine
DET (N,N-diethyltryptamine) or T-9 is a psychedelic drug closely related to DMT and 4-HO-DET. However, despite its structural similarity to DMT it is active orally around 50–100 mg without the aid of MAO inhibitors lasting about 2-4 hours. Additional recommended knowledge
PharmacologyThe mechanism of action is thought to be serotonin receptor agonism, much like other classic psychedelics.[1] BiochemistryThough DET is a synthetic compound with no known natural sources it has been used with mycelium of Psilocybe cubensis to produce the synthetic chemicals 4-PO-DET and 4-HO-DET, as opposed the naturally occurring 4-PO-DMT (Psilocybin) and 4-HO-DMT (Psilocin). Isolation of the alkaloids resulted in 3.3% 4-HO-DET and 0.01-0.8% 4-PO-DET.[2] Psychosis modelEarly studies of DET, as well as other psychedelics, mainly focused on the believed psychotomimetic properties.[3] Researchers theorized that abnormal metabolites of endogenous chemicals such as tryptamine, serotonin, and tryptophan could be the explanation for mental disorders as schizophrenia, or psychosis.[4] With the progression of science and pharmacological understanding this belief remains dismissed by most researchers. See alsoReferences
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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Diethyltryptamine". A list of authors is available in Wikipedia. |