Diethyltryptamine

DET (N,N-diethyltryptamine) or T-9 is a psychedelic drug closely related to DMT and 4-HO-DET. However, despite its structural similarity to DMT it is active orally around 50–100 mg without the aid of MAO inhibitors lasting about 2-4 hours.

Additional recommended knowledge

Correct Test Weight Handling Guide: 12 Practical Tips

Essential Laboratory Skills Guide

Weighing the right way

Pharmacology

The mechanism of action is thought to be serotonin receptor agonism, much like other classic psychedelics.^[1]

Biochemistry

Though DET is a synthetic compound with no known natural sources it has been used with mycelium of Psilocybe cubensis to produce the synthetic chemicals 4-PO-DET and 4-HO-DET, as opposed the naturally occurring 4-PO-DMT (Psilocybin) and 4-HO-DMT (Psilocin). Isolation of the alkaloids resulted in 3.3% 4-HO-DET and 0.01-0.8% 4-PO-DET.^[2]

Psychosis model

Early studies of DET, as well as other psychedelics, mainly focused on the believed psychotomimetic properties.^[3] Researchers theorized that abnormal metabolites of endogenous chemicals such as tryptamine, serotonin, and tryptophan could be the explanation for mental disorders as schizophrenia, or psychosis.^[4] With the progression of science and pharmacological understanding this belief remains dismissed by most researchers.

See also

• TiHKAL
• 5-MeO-DET
• 4-PO-DET (Ethocybin)
• Psychedelic tryptamines

References

1. ^ BEHAVIORAL EFFECTS OF N, N-DIETHYLTRYPTAMINE: ABSENCE OF ANTAGONISM BY XYLAMIDINE TOSYLATE -- WINTER 169 (1): 7 -- Journal of Pharmacology And Experimental Therapeutics. Retrieved on 2008-01-03.
2. ^ Biotransformation of tryptamine derivatives in myc...[J Basic Microbiol. 1989 - PubMed Result]. Retrieved on 2008-01-03.
3. ^ [http://www.erowid.org/references/refs_view.php?A=ShowDoc1&ID=2633 PSILOCYBIN AND DIETHYLTRYPTAMINE: TWO TRYPTAMINE HALLUCINOGENS]. Retrieved on 2008-01-03.
4. ^ Effects of LSD-25, N,N-Dimethyltryptamine (DMT), and N,N-Diethyltryptamine (DET) on the Photic Evoked Responses in the unanesthetized Rabbit. Retrieved on 2008-01-03.