Dicycloverine

Dicyclomine is an anticholinergic that blocks muscarinic receptors. Dicyclomine is known as dicycloverine hydrochloride in the UK.

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Clinical uses

Dicyclomine is used to treat intestinal hypermotility, the symptoms of Irritable Bowel Syndrome (IBS) (also known as spastic colon). It relieves muscle spasms in the gastrointestinal tract by blocking the activity of a certain natural substance in the body. It is a smooth muscle relaxer.

In America, it is sold under the trade names: Bentyl, Byclomine, Dibent, Di-Spaz, Dilomine.

It is sold under the trade names Bentylol (Hoechst Marion Roussel), Formulex (ICN), and Lomine (Riva) in Canada.

Side effects

Dicyclomine can cause a range of anticholinergic side effects such as dry mouth, nausea and at higher doses, deliriant effects. Abuse of this drug has been reported in Brazil.^[1]

Sources

1. ^ Carlini EA. Preliminary note: dangerous use of anticholinergic drugs in Brazil. Drug and Alcohol Dependence. 1993 Mar;32(1):1-7.

• Brenner, G. M. (2000). Pharmacology. Philadelphia, PA: W.B. Saunders Company. ISBN 0-7216-7757-6
• Canadian Pharmacists Association (2000). Compendium of Pharmaceuticals and Specialties (25th ed.). Toronto, ON: Webcom. ISBN 0-919115-76-4