Developmental studies hybridoma bank

The Developmental Studies Hybridoma Bank (or DSHB) was established in 1986 and is a source of hybridomas and hybridoma-related products of importance to developmental and cell biology. The Bank operates under the auspices of the National Institute of Child Health & Human Development, though has been self-funding since 1996³.

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The intent of the Bank is three-fold⁵:

• keep the price of monoclonal antibodies low
• relieve scientists from the administrative and financial burden of distributing hybridomas they have developed
• maintain an archival resource of monoclonals that might otherwise be lost due to low demand

The Bank is currently administered by Dr. David R. Soll of the University of Iowa¹. More than 600 hybridoma lines are currently available⁴. Hybridomas are available for a fee (credit cards accepted), contingent on agreement to a compliance statement indicating that the reagents will be used for research purposes only, that published manuscripts citing use of the reagents be provided to the facility, and that such manuscripts cite the originators of the reagents as well. ²

Among the antigens targeted by monoclonals produced by Bank hybridomas are those associated with⁶:

• cytoskeletal and extracellular matrix elements
• proteins involved in neural function and development
• cell cycle proteins
• transcription factors
• ~100 Drosophila proteins

References

Note 1: [1]. Retrieved 2005-02-03. Note 2: Access to compliance and order form. Retrieved 2005-02-03. Note 4: ibid. Note 5: ibid. Note 6: ibid.