To use all functions of this page, please activate cookies in your browser.
my.bionity.com
With an accout for my.bionity.com you can always see everything at a glance – and you can configure your own website and individual newsletter.
- My watch list
- My saved searches
- My saved topics
- My newsletter
Des-gamma carboxyprothrombinDes-gamma carboxyprothrombin (DCP), also known as protein induced by vitamin K absence/antagonist-II (PIVKA-II), is an abnormal form of the coagulation protein, prothrombin. Normally, the prothrombin precursor undergoes post-translational carboxylation (addition of a carboxylic acid group) by gamma-glutamyl carboxylase in the liver prior to secretion into plasma. DCP/PIVKA-II may be detected in people with deficiency of vitamin K (due to poor nutrition or malabsorption) and in those taking warfarin or other medication that inhibits the action of vitamin K. Additional recommended knowledge
Diagnostic useHepatocellular carcinomaA 1984 study first described the use of DCP as a marker of hepatocellular carcinoma (HCC); it was present in 91% of HCC patients, while not being detectable in other liver diseases. The DCP level did not change with the administration of vitamin K, suggesting a defect in gamma-carboxylation activity rather than vitamin K deficiency.[1] A number of subsequent studies have since confirmed this phenomenon.[2][3][4] A 2007 comparison of various HCC tumor markers found DCP the least sensitive to risk factors for HCC (such as cirrhosis), and hence the most useful in predicting HCC.[5] It differentiates HCC from non-malignant liver diseases.[6] Despite many years of use in Japan, only did a 2003 American study reevaluate its use in an American patient series. It also identified HCC at an earlier stage.[4] Anticoagulant intoxicationA 1987 report described the use of DCP determination in the detection of intoxication with acenocoumarol, a vitamin K antagonist.[7] References
Categories: Coagulation system | Tumor markers |
|
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Des-gamma_carboxyprothrombin". A list of authors is available in Wikipedia. |