Derepression

In biochemistry, a repressor gene inhibits the activity of an operator gene. By inactivating the repressor, the operator gene becomes active again. This effect is called derepression.

Derepression of ALA synthase

Additional recommended knowledge

Daily Visual Balance Check

How to quickly check pipettes?

Don't let static charges disrupt your weighing accuracy

One example is the effect of drugs on the activity of ALA synthase, an enzyme involved in heme-synthesis. When inducing for example phenobarbital, griseofulvin or hydantoins, the activity of ALA synthase will rise. The cause is a production of cytochrome P450-production, induced by the drugs, consuming heme. When the amount of heme in the liver decreases, it no longer act as a repressor for its synthesis. On the contrary, ALA synthase increases which leads to an increase in heme-production.

References

• Pamela C., Ph.D. Champe, Richard A., Ph.D. Harvey, Denise R., Ph.D. Ferrier, (2004). Lippincott's Illustrated Reviews: Biochemistry 319, 3rd edition, Hagerstwon, MD: Lippincott Williams & Wilkins. ISBN 0-7817-2265-9.