Depolarization

In biology, depolarization is a decrease in the absolute value of a cell's membrane potential. Thus, changes in membrane voltage in which the membrane potential becomes less positive or less negative are both depolarizations. In neurons and some other cells, a depolarization large enough may result in an action potential. Hyperpolarization is the opposite of depolarization, and inhibits the rise of an action potential. The rising and falling phases of such an action potential are often imprecisely also called depolarization and hyperpolarization, respectively.

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Mechanism

Depolarization is often caused by influx of cations, e.g. Na⁺ through Na⁺ channels, or by influx of Ca²⁺ through Ca²⁺ channels.

On the other hand, outflux of K⁺ through K⁺ channels inhibits depolarization.

Depolarization block

There are drugs, called depolarization blocking agents, that inhibit depolarization, e.g. by blocking the channels responsible for depolarization, or by opening K⁺ channels. Examples include the nicotinic agonists suxamethonium and decamethonium^[1].

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