Dense Fibrillar Component (DFC)

This component is also made up by very fine (3-5 nm) and densely packed fibrils. DFCs usually surround FCs when they are present and form a meshwork. ribosome biogenesis. Sometimes this meshwork occupies large areas of the nucleolus, occasionally interspersed with small FCs.

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During S phase of cell cycle, the increase in upstream binding factor (UBF) association may be due to the increase in its ability to compete with the histones for binding to the DNA.