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Deguelin

Deguelin

IUPAC name	(7aS,13aS)-13,13a-Dihydro-9,10- dimethoxy-3,3-dimethyl-3H-bis[1] benzopyrano [3,4-b:6’,5’-3] pyran-7(7aH)-one
Other names	Deguelin
Identifiers
CAS number	522-17-8
Properties
Molecular formula	C₂₃H₂₂O₆
Molar mass	394.42 g/mol
Melting point	171 °C
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references

Deguelin is a derivative of rotenone. Both are compounds classified as rotenoids of the flavonoid family and are naturally occurring insecticides. They can be produced by extraction from several plant species belonging to three genera of the Fabaceae or Legume family, Lonchocarpus, Derris, or Tephrosia.

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Cubé resin, the root extract from Cubé (Lonchocarpus utilis) and from Barbasco (Lonchocarpus urucu), is used as a commercial insecticide and piscicide (fish poison). The major active ingredients are rotenone and deguelin. Although "organic" (produced by nature) cubé resin is no longer considered environmentally safe.

Deguelin is being investigated for its anti-cancer activity (inhibiting the growth of pre-cancerous and cancerous cells) - particularly for lung cancer. So far the compound has shown no toxic effects on normal cells. However, high doses of deguelin are suspected of having negative effects on the heart, lungs and nerves.

Deguelin and Parkinson's disease

Research has shown a correlation between intravenous deguelin and Parkinson's disease in rats. The study does not suggest that deguelin exposure is responsible for Parkinson's disease in humans, but is consistent with the belief that chronic exposure to environmental toxins can increase the likelihood of the disease.