Craig plot

The Craig plot is a plot of two substituent parameters (e.g. Hansch-Fujita p and Hammett σ values) used in rational drug design.

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Two most used forms of a Craig plot are

• plotting the sigma constants of the Hammett equation versus hydrophobicity
• plotting the steric terms of the Taft equation against hydrophobicity

See also

• Quantitative structure-activity relationship
• pKa

References

• [IUPAC glossary|http://www.iupac.org/reports/1997/6905vandewaterbeemd/glossary.html]