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Colton antigen systemThe Colton antigen system (Co) is present on the membranes of red blood cells and in the tubules of the kidney[1] and helps determine a person's blood type. The Co antigen is found on a protein called aquaporin-1 which is responsible for water homeostasis and urine concentration.[2] Additional recommended knowledgeThe Co antigen is important in transfusion medicine. 99.8% of people possess the Co(a) allele. Individuals with Co(b) allele or who are missing the Colton antigen are at risk for a transfusion reaction such as hemolytic anemia or alloimmunization. Antibodies against the Colton antigen may also cause hemolytic disease of the newborn, in which a pregnant woman's body creates antibodies against the blood of her fetus, leading to destruction of the fetal blood cells.[3] References
Categories: Transfusion medicine | Blood antigen systems |
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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Colton_antigen_system". A list of authors is available in Wikipedia. |