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Chlorobutanol

Chlorobutanol

IUPAC name	1,1,1-Trichloro-2-methyl-2-propanol
Other names	1,1,1-trichloro-2-methyl-2-propanol, chlorbutol, chloreton, chloretone, chlortran, trichloro-tert-butyl alcohol, 1,1,1-trichloro-tert-butyl alcohol, 2-(trichloromethyl)propan-2-ol, 1,1,1-trichloro-2-methyl-2-propanol, tert-Trichlorobutyl alcohol, trichloro-tert-butanol, trichlorisobutylalcohol, 2,2,2-trichloro-1,1-dimethylethanol
Identifiers
CAS number	57-15-8
Properties
Molecular formula	C₄H₇Cl₃O
Molar mass	175.5 g/mol
Appearance	White solid
Melting point	95 - 99°C
Boiling point	167°C
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references

Chlorobutanol, or 1,1,1-trichloro-2-methyl-2-propanol, is a chemical preservative, sedative hypnotic and weak local anaesthetic similar in nature to chloral hydrate.

Additional recommended knowledge

Don't let static charges disrupt your weighing accuracy

Daily Sensitivity Test

Correct Test Weight Handling Guide: 12 Practical Tips

Chemical synthesis

Chlorobutanol is formed by the simple nucleophilic addition of chloroform and acetone. The reaction is base driven by potassium or sodium hydroxide.

v • d • e Antiemetics and antinauseants (A04)
Serotonin (5-HT₃) antagonists	Ondansetron • Granisetron • Tropisetron • Dolasetron • Palonosetron
Other	Scopolamine • Cerium oxalate • Chlorobutanol • Metopimazine • Cannabinoids (Dronabinol, Nabilone) • NK1 receptor antagonist (Aprepitant)