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Casein kinase 2

The Casein kinase 2 (EC 2.7.11.1) is a serine/threonine-selective protein kinase that is a tetramer of two alpha subunits and two beta subunits. The alpha subunits have the catalytic kinase domain. Casein kinase 2 has been implicated in cell cycle control, DNA repair, regulation of the circadian rhythm and other cellular processes.

casein kinase 2, alpha 1 polypeptide
Identifiers
Symbol(s)	CSNK2A1
Entrez	1457
OMIM	115440

casein kinase 2, alpha prime polypeptide
Identifiers
Symbol(s)	CSNK2A2
Entrez	1459
OMIM	115442

casein kinase 2, beta polypeptide
Identifiers
Symbol(s)	CSNK2B
Entrez	1460
OMIM	115441

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Casein kinase 2 activity has been reported to be activated following Wnt signaling pathway activation^[1]. A Pertussis toxin-sensitive G protein and Dishevelled appear to be an intermediary between Wnt-mediated activation of the Frizzled receptor and activation of casein kinase 2.

Mice that lack casein kinase 2 alpha prime have a defect in the morphology of developing sperm ^[2]

References

^ Y. Gao and H. Y. Wang (2006) "Casein kinase 2 is activated and essential for wnt/beta-catenin signaling" in Journal of Biological Chemistry Entrez PubMed 16672224
^ X. Xu, P. Toselli, L. Russell and D. Seldin (1999) "Globozoospermia in mice lacking the casein kinase II alpha' catalytic subunit" in Nature Genetics Volume 23, pages 118-121. Entrez PubMed 10471512

v • d • e cell signaling
Key concepts	Ligand - Cell signaling networks - Signal transduction - Apoptosis - Second messenger system (Ca²⁺ signaling, Lipid signaling)
Processes	Paracrine - Autocrine - Juxtacrine - Neurotransmitters - Endocrine (Neuroendocrine)
Types of proteins	Receptor (Transmembrane, Intracellular) - Transcription factor (General, Preinitiation complex, TFIID, TFIIH) - Adaptor protein