Casein kinase 2

The Casein kinase 2 (EC 2.7.11.1) is a serine/threonine-selective protein kinase that is a tetramer of two alpha subunits and two beta subunits. The alpha subunits have the catalytic kinase domain. Casein kinase 2 has been implicated in cell cycle control, DNA repair, regulation of the circadian rhythm and other cellular processes.

Additional recommended knowledge

How to quickly check pipettes?

Essential Laboratory Skills Guide

Don't let static charges disrupt your weighing accuracy

Casein kinase 2 activity has been reported to be activated following Wnt signaling pathway activation^[1]. A Pertussis toxin-sensitive G protein and Dishevelled appear to be an intermediary between Wnt-mediated activation of the Frizzled receptor and activation of casein kinase 2.

Mice that lack casein kinase 2 alpha prime have a defect in the morphology of developing sperm ^[2]

See also

• CSNK2A1
• CSNK2A2
• Casein kinase 1 - a distinct protein kinase family

References