Carbamoyl phosphate

Carbamoyl phosphate is an anion of biochemical significance. It is involved In ridding the body of excess nitrogen in the urea cycle, and also in the synthesis of pyrimidines.

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It is produced from bicarbonate, ammonia, and phosphate, the latter derived from ATP. The synthesis is catalysed by the enzyme carbamoyl phosphate synthase, as follows:

• HCO₃^- + ATP --> ADP + HO-C(O)-OPO₃^-2 (carbonyl phosphate)
• HO-C(O)-OPO₃^-2 + NH₃ + OH^- → HPO₄^2- + ^-O-C(O)NH₂ + H₂O
• ^-O-C(O)NH₂ + ATP → ADP + H₂NC(O)OPO₃^2-

See also

• Ornithine transcarbamylase

References

• Nelson, David L. and Michael M. Fox. Lehninger Principles of Biochemistry fourth edition. W. H. Freeman and company New York.