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Canine discoid lupus erythematosus
Probably the best-known human sufferer of the condition is the singer Seal, who contracted it as a child and has distinctive scars on his upper cheeks. Additional recommended knowledge
SymptomsThe most common initial symptom is scaling and loss of pigment on the nose. This is found in up to 90 percent of dogs.[2] The surface of the nose becomes smooth gray, and ulcerated, instead of the normal black cobblestone texture. Over time the lips, the skin around the eyes, the ears, and the genitals may become involved.[6] Lesions may progress to ulceration and lead to tissue destruction. DLE is often worse in summer due to increased sun exposure. DiagnosisDLE is easily confused with solar dermatitis, pemphigus, ringworm, and other types of dermatitis. Biopsy is required to make the distinction. Histopathologically, there is inflammation at the dermoepidermal junction and degeneration of the basal cell layer.[5] Unlike in SLE, an anti-nuclear antibody test is usually negative.[2] TreatmentAvoiding sun exposure and the use of sunscreens (not containing zinc oxide, which is toxic to dogs) is important. Topical therapy includes corticosteroid use. Oral vitamin E or omega-3 and omega-6 fatty acids are also used. More refractory cases may require the use of oral niacinamide and tetracycline, corticosteroids, azathioprine, or chlorambucil.[7] Treatment is often lifelong, but there is a good prognosis for longterm remission. Commonly affected dog breeds
See alsoReferences
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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Canine_discoid_lupus_erythematosus". A list of authors is available in Wikipedia. |