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Calciseptine
Calciseptine (CaS) is a natural neurotoxin isolated from the black mamba Dendroaspis p. polylepis venom. This toxin consists of 60 amino acids with four disulfide bonds. Calciseptine specifically blocks L-Type calcium channels, but not other voltage-dependent Ca2+ channels such as N-type and T-type channels.[1] Additional recommended knowledge
SequenceIts amino acid sequence is: RICYI HKASL PRATK TCVEN TCYKM FIRTQ REYIS REGCG CPTAM WPYQT ECCKG DRCNK IsolationCalciseptine is purified from the venom of black mamba Dendroaspis p. polyepsis via three isolation steps: (1) gel filtration, (2) ion exchange on TSK SP 5PW, and (3) reverse-phase chromatograghy on RP18. It represents 2.8% of the total venom components. [2] TargetCalciseptine blocks L-type Ca2+ channels.[1] As a result, it blocks spontaneous contractions of rat portal vein, contractions of the rat thoracic aorta, uterus and cardiac preparations. References
Categories: Neurotoxins | Toxicology | Ion channel toxins |
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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Calciseptine". A list of authors is available in Wikipedia. |