Cytochrome P450, family 2, subfamily C, polypeptide 9
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Ribbon diagram of CYP2C9, heme group visible at center. From PDB 1OG2.
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Available structures: 1og2, 1og5, 1r9o
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Identifiers
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Symbol(s)
| CYP2C9; CYP2C; CPC9; CYP2C10; MGC149605; MGC88320; P450 MP-4; P450 PB-1; P450IIC9
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External IDs
| OMIM: 601130 MGI: 103238 Homologene: 86657
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Gene Ontology
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Molecular Function:
| • iron ion binding • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen • (S)-limonene 6-monooxygenase activity • (S)-limonene 7-monooxygenase activity • heme binding • metal ion binding
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Cellular Component:
| • endoplasmic reticulum • microsome • membrane
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Biological Process:
| • electron transport
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RNA expression pattern
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More reference expression data
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Orthologs
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| Human
| Mouse
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Entrez
| 1559
| 13095
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Ensembl
| ENSG00000138109
| ENSMUSG00000003053
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Uniprot
| P11712
| Q3UEF2
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Refseq
| NM_000771 (mRNA) NP_000762 (protein)
| NM_007815 (mRNA) NP_031841 (protein)
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Location
| Chr 10: 96.69 - 96.74 Mb
| Chr 19: 39.34 - 39.38 Mb
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Pubmed search
| [1]
| [2]
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Cytochrome P450 2C9 (abbreviated CYP2C9), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the body. It is involved in the metabolism of several important groups of drugs including many non-steroidal anti-inflammatory drugs (NSAIDs) and sulfonylureas.
Genetic polymorphism exists for CYP2C9 expression, with approximately 1–3% of Caucasian populations being poor metabolisers with no CYP2C9 function.
Additional recommended knowledge
CYP2C9 Ligands
Selected inducers, inhibitors and substrates of CYP2C9[1]
Substrates | Inhibitors | Inducers
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Often mentioned [2]:
Other:
| Strong [3]:
others:
| Often mentioned [2]:
Other:
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See also
References
- ^ Where classes of agents are listed, there may be exceptions within the class
- ^ a b Mentioned both in the reference named FASS and were previously mentioned in Wikipedia. Further contributions may follow other systems
- ^ Swedish environmental classification of pharmaceuticals Facts for prescribers (Fakta för förskrivare)
Further reading
- Goldstein JA, de Morais SM (1995). "Biochemistry and molecular biology of the human CYP2C subfamily.". Pharmacogenetics 4 (6): 285-99. PMID 7704034.
- Miners JO, Birkett DJ (1998). "Cytochrome P4502C9: an enzyme of major importance in human drug metabolism.". British journal of clinical pharmacology 45 (6): 525-38. PMID 9663807.
- Smith G, Stubbins MJ, Harries LW, Wolf CR (1999). "Molecular genetics of the human cytochrome P450 monooxygenase superfamily.". Xenobiotica 28 (12): 1129-65. PMID 9890157.
- Henderson RF (2001). "Species differences in the metabolism of olefins: implications for risk assessment.". Chem. Biol. Interact. 135-136: 53-64. PMID 11397381.
- Xie HG, Prasad HC, Kim RB, Stein CM (2003). "CYP2C9 allelic variants: ethnic distribution and functional significance.". Adv. Drug Deliv. Rev. 54 (10): 1257-70. PMID 12406644.
- Palkimas MP, Skinner HM, Gandhi PJ, Gardner AJ (2004). "Polymorphism induced sensitivity to warfarin: a review of the literature.". J. Thromb. Thrombolysis 15 (3): 205-12. doi:10.1023/B:THRO.0000011376.12309.af. PMID 14739630.
- Daly AK, Aithal GP (2004). "Genetic regulation of warfarin metabolism and response.". Seminars in vascular medicine 3 (3): 231-8. doi:10.1055/s-2003-44458. PMID 15199455.
- García-Martín E, Martínez C, Ladero JM, Agúndez JA (2007). "Interethnic and intraethnic variability of CYP2C8 and CYP2C9 polymorphisms in healthy individuals.". Molecular diagnosis & therapy 10 (1): 29-40. PMID 16646575.
Cytochromes, oxygenases: cytochrome P450 (EC 1.14) |
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CYP1 | A1, A2, B1 |
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CYP2 | A6, A7, A13, B6, C8, C9, C18, C19, D6, E1, F1, J2, R1, S1, U1, W1 |
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CYP3 | A4, A5, A7, A43 |
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CYP4 | A11, A22, B1, F2, F3, F8, F11, F12, F22, V2, X1, Z1 |
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CYP5-20 | CYP5 (A1) - CYP7 (A1, B1) - CYP8 (A1, B1) - CYP11 (A1, B1, B2) - CYP17 (A1) - CYP19 (A1) - CYP20 (A1) |
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CYP21-51 | CYP21 (A2) - CYP24 (A1) - CYP26 (A1, B1, C1) - CYP27 (A1, B1, C1) - CYP39 (A1) - CYP46 (A1) - CYP51 (A1) |
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